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一氧化碳暴露对兔主动脉和冠状动脉内膜形态的影响。一项重新评估。

Effect of carbon monoxide exposure on aortic and coronary intimal morphology in the rabbit. A revaluation.

作者信息

Hugod C, Hawkins L H, Kjeldsen K, Thomsen H K, Astrup P

出版信息

Atherosclerosis. 1978 Aug;30(4):333-42. doi: 10.1016/0021-9150(78)90126-0.

DOI:10.1016/0021-9150(78)90126-0
PMID:708490
Abstract

Non-cholesterol-fed rabbits were exposed to carbon monoxide at concentrations in air of either 200, 2000, or 4000 parts per million (=0.02, 0.2 or 0.4%, vol/vol). Using the same criteria for intimal damage as in earlier morphological studies, no histotoxic effect on intimal/subintimal morphology of coronary arteries or the aorta could be demonstrated, when light-microscopic evaluation was performed blindly.

摘要

未喂食胆固醇的兔子暴露于空气中一氧化碳浓度分别为百万分之200、2000或4000(即0.02%、0.2%或0.4%,体积/体积)的环境中。按照与早期形态学研究相同的内膜损伤标准,在进行盲法光学显微镜评估时,未发现对冠状动脉或主动脉内膜/内膜下形态有组织毒性作用。

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Effect of carbon monoxide exposure on aortic and coronary intimal morphology in the rabbit. A revaluation.一氧化碳暴露对兔主动脉和冠状动脉内膜形态的影响。一项重新评估。
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引用本文的文献

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In vivo oxygen transport in the normal rabbit femoral arterial wall.
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The effect of carbon monoxide exposure on morphology of lungs and pulmonary arteries in rabbits. A light- and electron-microscopic study.一氧化碳暴露对兔肺及肺动脉形态的影响。光镜和电镜研究。
Arch Toxicol. 1980 Feb;43(4):273-81. doi: 10.1007/BF00366183.
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Carboxyhaemoglobin levels in workers in Leicestershire garages.莱斯特郡汽车修理厂工人的碳氧血红蛋白水平。
Br J Ind Med. 1980 May;37(2):197. doi: 10.1136/oem.37.2.197.
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Is there a connection between carbon monoxide exposure and hypertension?一氧化碳暴露与高血压之间存在关联吗?
Environ Health Perspect. 1991 Nov;95:191-8. doi: 10.1289/ehp.9195191.
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Exposure of rabbits to 50 ppm carbonyl sulfide. A biochemical and histomorphological study.
Int Arch Occup Environ Health. 1979 Sep;44(2):109-16. doi: 10.1007/BF00386744.
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Cardiovascular disease and environmental exposure.心血管疾病与环境暴露
Br J Ind Med. 1979 May;36(2):85-97. doi: 10.1136/oem.36.2.85.
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Effect of exposure to 0.5 ppm hydrogen cyanide singly or combined with 200 ppm carbon monoxide and/or 5 ppm nitric oxide on coronary arteries, aorta, pulmonary artery, and lungs in the rabbit.
Int Arch Occup Environ Health. 1979 Aug;44(1):13-23. doi: 10.1007/BF00381205.