Willford D C, Hill E P, Moores W Y
J Appl Physiol Respir Environ Exerc Physiol. 1982 Apr;52(4):1043-8. doi: 10.1152/jappl.1982.52.4.1043.
A simple expression is derived to describe the partial pressure at 50% hemoglobin saturation with oxygen (P50) that maximizes venous oxygen tension (PO2) for a given arterial PO2 and oxygen consumption. That "optimal P50" also maximizes arteriovenous saturation differences for given arterial and venous PO2 values. The optimal P50 can be expressed as the square root of the product of arterial and venous PO2 values. Alternatively, it can be expressed as a simple function of the arterial PO2 and the arteriovenous saturation difference. Nomograms summarize the relationships between the variables, and published observations that suggest an observational basis for our theoretical analysis are reviewed. We conclude that for normoxia or moderate hypoxia a high P50 is advantageous, whereas for more severe hypoxia or increased metabolic demands, a low P50 is advantageous.
推导得出一个简单表达式，用于描述血红蛋白氧饱和度为50%时的分压（P50），该分压能在给定动脉氧分压（PO2）和氧耗量的情况下使静脉氧张力（PO2）最大化。对于给定的动脉和静脉PO2值，“最佳P50”还能使动静脉饱和度差异最大化。最佳P50可表示为动脉和静脉PO2值乘积的平方根。或者，它也可以表示为动脉PO2和动静脉饱和度差异的简单函数。列线图总结了各变量之间的关系，并对已发表的观察结果进行了综述，这些观察结果为我们的理论分析提供了观察依据。我们得出结论，对于常氧或中度缺氧，高P50是有利的，而对于更严重的缺氧或代谢需求增加，低P50是有利的。
