Shen R, Smith R V, Davis P J, Brubaker A, Abell C W
J Biol Chem. 1982 Jul 10;257(13):7294-7.
Dopamine-derived tetrahydroisoquinolines, such as 3',4'-deoxynorlaudanosolinecarboxylic acid, higenamine-1-carboxylic acid, higenamine, and salsolinol, inhibit human liver dihydropteridine reductase noncompetitively with Ki values ranging from 1.5 to 90 microM. The enzyme is also inhibited noncompetitively by dopamine (Ki = 6 microM) and aminopterin (Ki = 100 microM) but uncompetitively by phenylpyruvic acid (Ki = 6.5 mM). These alkaloids may alter monoamine metabolism in mammals by inhibiting dihydropteridine reductase.
多巴胺衍生的四氢异喹啉，如3'，4'-脱氧去甲劳丹索羧酸、去甲乌药碱-1-羧酸、去甲乌药碱和salsolinol，对人肝二氢蝶啶还原酶具有非竞争性抑制作用，其Ki值范围为1.5至90微摩尔。该酶也受到多巴胺（Ki = 6微摩尔）和氨甲蝶呤（Ki = 100微摩尔）的非竞争性抑制，但受到苯丙酮酸（Ki = 6.5毫摩尔）的反竞争性抑制。这些生物碱可能通过抑制二氢蝶啶还原酶来改变哺乳动物体内的单胺代谢。
