多巴胺对二氢蝶啶还原酶的抑制作用。
Inhibition of dihydropteridine reductase by dopamine.
作者信息
Purdy S E, Blair J A, Barford P A
出版信息
Biochem J. 1981 Jun 1;195(3):769-71. doi: 10.1042/bj1950769.
Abstract
Dihydropteridine reductase has been purified 900-fold from rat liver. Dopamine inhibited the enzyme up to 50% at a concentration of 0.11mm. In the presence of dopamine the enzyme gave non-hyperbolic v-against-[S] plots. This enzyme may have a role in control of dopamine biosynthesis.
摘要
二氢蝶啶还原酶已从大鼠肝脏中纯化了900倍。多巴胺在浓度为0.11毫摩尔时可抑制该酶达50%。在多巴胺存在的情况下，该酶的v对[S]曲线呈非双曲线形。这种酶可能在多巴胺生物合成的控制中起作用。
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