患有乳糜泻的儿童十二指肠黏膜中组胺的组织浓度升高。
Increased tissue concentrations of histamine in the duodenal mucosa of children with coeliac disease.
作者信息
Challacombe D N, Dawkins P D
出版信息
J Clin Pathol. 1982 Jun;35(6):596-8. doi: 10.1136/jcp.35.6.596.
Tissue concentrations of histamine have been estimated in peroral duodenal biopsy specimens from five children with coeliac disease while on a gluten-free diet and after a three-month gluten challenge. Histamine concentrations in the patients on a diet did not differ significantly from a group of control children. However after gluten challenge, histological relapse of the duodenal mucosa in each patient was associated with increased tissue concentrations of histamine. The findings suggest that histamine may be involved in the pathogenesis of the small intestinal mucosal changes in children with coeliac disease.
已对五名乳糜泻患儿在无麸质饮食期间以及经过三个月的麸质激发试验后，经口获取的十二指肠活检标本中的组胺组织浓度进行了评估。采用无麸质饮食的患儿体内组胺浓度与一组对照儿童相比无显著差异。然而，在麸质激发试验后，每名患儿十二指肠黏膜的组织学复发均与组胺组织浓度升高有关。这些发现表明，组胺可能参与了乳糜泻患儿小肠黏膜病变的发病机制。
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