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匈牙利人群中HLA B27的分布与强直性脊柱炎

Distribution of HLA B27 and ankylosing spondylitis in the Hungarian population.

作者信息

Gömör B, Gyodi E, Bakos L

出版信息

J Rheumatol Suppl. 1977;3:33-5.

PMID:266594
Abstract

On the basis of (a) our epidemiological studies of ankylosing spondylitis (AS) (males 0.4 per cent, females 0.08 per cent), (b) typing of 352 normal persons (frequency of HLA B27 = 12.78 per cent), and (c) typing of 55 AS patients (frequency of HLA B27 = 92.73 per cent), we have calculated the prevalence of AS for the total Hungarian population over 15 years of age. Among males with the B27 anitgen, AS occurs in 2.9 per cent, and in B27 positive females 0.58 per cent. In the population without the B27 antigen, the prevalence of the disease is 0.03 per cent and 0.006 per cent respectively. The quotients of these data show that a person with the B27 antigen has approximately 87 times greater risk of developing AS, than does a person of the same sex without this antigen.

摘要

基于以下几点

(a)我们对强直性脊柱炎(AS)的流行病学研究(男性发病率为0.4%,女性为0.08%);(b)对352名正常人进行的分型(HLA B27频率为12.78%);(c)对55名AS患者进行的分型(HLA B27频率为92.73%),我们计算了匈牙利15岁以上总人口中AS的患病率。在携带B27抗原的男性中,AS发病率为2.9%,在B27阳性女性中为0.58%。在不携带B27抗原的人群中,该病的患病率分别为0.03%和0.006%。这些数据的商数表明,携带B27抗原的人患AS的风险大约是不携带该抗原的同性别的人的87倍。

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