Williams D M, Lampert I A, Evans D J
Br J Haematol. 1978 Sep;40(1):119-24. doi: 10.1111/j.1365-2141.1978.tb03645.x.
Leucocyte alkaline phosphatase (LAP) levels have been compared in neutrophil polymorphs in bone marrow and blood in the rat, using a quantitative enzyme cytochemical technique. It has been shown that LAP levels are higher in bone marrow than blood, both in normal animals and those with experimentally-induced local inflammatory lesions. In the latter group both marrow and blood LAP levels were higher than in controls; blood levels rose because of the outpouring of cells with moderately high LAP levels into the blood and marrow levels rose because only cells with very high LAP levels remained. The inverse relationship between neutrophil age and alkaline phosphatase content, previously demonstrated in the peripheral blood of the rat, has also been shown to exist in the bone marrow.
采用定量酶细胞化学技术，对大鼠骨髓和血液中中性多形核白细胞的白细胞碱性磷酸酶（LAP）水平进行了比较。结果表明，无论是正常动物还是实验性诱导局部炎症病变的动物，骨髓中的LAP水平均高于血液。在后一组中，骨髓和血液中的LAP水平均高于对照组；血液中LAP水平升高是因为LAP水平中等偏高的细胞涌入血液，而骨髓中LAP水平升高是因为仅留存了LAP水平非常高的细胞。先前在大鼠外周血中证实的中性粒细胞年龄与碱性磷酸酶含量之间的负相关关系，在骨髓中也得到了证实。
