Izadian N
J R Soc Med. 1982 Jun;75(6):435-42. doi: 10.1177/014107688207500612.
Direct chromosome preparations were made from 52 malignant and 21 non-malignant effusions. An effusion was classified as malignant if 2% of the counted cells showed abnormal karyotypes. There was a significant relationship between diversified karyotypes and the pathological nature of tumours: diversity of karyotypes was much higher in undifferentiated adenocarcinoma, anaplastic carcinoma and embryonal cell carcinoma cells than in well-differentiated cancer cells. Diagnosis was positive for 38 of the 52 malignant effusions by cytological examination (73% sensitivity), and positive for 41 of the 52 by cytogenetic analysis (78% sensitivity). There were no false positive results using both cytogenetic and cytologic examinations (92% sensitivity). Particularly in patients with equivocal cytology, cytogenetic analysis appears to be a useful tool in the diagnosis of malignant effusions.
直接染色体标本取自52例恶性积液和21例非恶性积液。如果在计数的细胞中有2%显示核型异常，则该积液被分类为恶性。核型多样性与肿瘤的病理性质之间存在显著关系：未分化腺癌、间变性癌和胚胎癌细胞中的核型多样性远高于高分化癌细胞。52例恶性积液中有38例经细胞学检查诊断为阳性（敏感性73%），52例中有41例经细胞遗传学分析诊断为阳性（敏感性78%）。细胞遗传学和细胞学检查均未出现假阳性结果（敏感性92%）。特别是在细胞学检查结果不明确的患者中，细胞遗传学分析似乎是诊断恶性积液的有用工具。
