Thüroff J W, Bazeed M A, Schmidt R A, Wiggin D M, Tanagho E A
J Urol. 1982 May;127(5):1031-3. doi: 10.1016/s0022-5347(17)54182-8.
Prior to this study, electrostimulation of the ventral sacral roots had only limited success in evacuation of the bladder because dyssynergic sphincter contraction simultaneously increased urethral resistance. Thus, pudendal nerve blockade, pudendal neurotomy, selective peripheral neurotomy, or external sphincterotomy for reduction of sphincteric resistance seemed inevitable. To avoid those procedures we used electrical sphincter fatigue to induce effective micturition with stimulation of the ventral sacral roots. Stimuli of 200 Hz frequency rapidly fatigue the dyssynergic sphincteric response but not the desired detrusor contraction, eliminating the need of interference with the sphincteric activity.
在本研究之前，电刺激骶前根在促进膀胱排空方面仅取得有限成功，因为协同失调的括约肌收缩会同时增加尿道阻力。因此，进行阴部神经阻滞、阴部神经切断术、选择性周围神经切断术或外括约肌切开术以降低括约肌阻力似乎是不可避免的。为避免这些手术，我们利用电刺激使括约肌疲劳，通过刺激骶前根来诱导有效的排尿。200赫兹频率的刺激能迅速使协同失调的括约肌反应疲劳，但不会使所需的逼尿肌收缩疲劳，从而无需干扰括约肌活动。
