Thüroff J W, Bazeed M A, Schmidt R A, Wiggin D M, Tanagho E A
J Urol. 1982 May;127(5):1034-8. doi: 10.1016/s0022-5347(17)54183-x.
Ten dogs were used for electrostimulation of the sacral roots to improve urethral sphincter closure. To induce and maintain urethral closure in longstanding stimulation, a variety of stimulation patterns was investigated systematically. With continuous stimulation, the induced sphincteric response faded corresponding with the increase in frequency of stimulation applied, but in phasic stimulation with a stimulation/rest ratio of 1:2, strong sphincteric contractions were reproducible after each rest interval. If the stimulation bursts were shortened to 30-60 msec., interrupted by an off-time of again twice the duration of the stimulation, unfused sphincteric tetani were induced, resulting in a sinusoidal oscillating closure pressure that did not drop in the prestimulus baseline during the off-time. A sufficient sphincteric closure pressure could thus be sustained over 1 hour of uninterrupted stimulation.
选用10只犬对其骶神经根进行电刺激，以改善尿道括约肌闭合功能。为了在长期刺激中诱导并维持尿道闭合，系统地研究了多种刺激模式。在持续刺激时，随着刺激频率的增加，诱导产生的括约肌反应逐渐消退，但在刺激/休息比为1:2的相位刺激中，每次休息间隔后都能重现强烈的括约肌收缩。如果将刺激脉冲缩短至30 - 60毫秒，并由再次为刺激持续时间两倍的关闭时间中断，则会诱导出未融合的括约肌强直收缩，从而产生正弦振荡闭合压力，在关闭时间内该压力不会降至刺激前基线水平。因此，在1小时的不间断刺激中能够维持足够的括约肌闭合压力。
