Vadlamani N L, Pontani R B, Misra A L
Pharmacol Biochem Behav. 1982 May;16(5):847-50. doi: 10.1016/0091-3057(82)90247-7.
Disposition of [H] Phencyclidine in brain, plasma and adipose tissue of rats acutely and chronically-treated with ethanol was studied using a method possessing high sensitivity and specificity for PCP. In rats acutely-treated with ethanol (5 g/kg PO dose) and PCP (10 mg/kg IP dose), dispositional factors did not play a role in the intensifies pharmacological and behavioral effects of PCP. However in rats chronically-treated with 2.5 g/kg PO dose of ethanol twice a day for 19 days, the disposition of PCP (5 mg/kg IP dose) was significantly altered and the values of PCP in brain, plasma and adipose tissue were significantly higher than those in the control group. Although inhibition of PCP metabolism and a comparatively slower rate of its elimination appear to account for the potentiation of drug effects in animals chronically-treated with ethanol, interaction of drugs at the level of the central nervous system cannot be ruled out.
使用一种对苯环己哌啶具有高灵敏度和特异性的方法，研究了急性和慢性乙醇处理大鼠的脑、血浆和脂肪组织中[H]苯环己哌啶的分布情况。在急性给予乙醇（口服剂量5 g/kg）和苯环己哌啶（腹腔注射剂量10 mg/kg）的大鼠中，分布因素在苯环己哌啶增强的药理和行为效应中不起作用。然而，在每天两次口服2.5 g/kg乙醇，持续19天的慢性处理大鼠中，苯环己哌啶（腹腔注射剂量5 mg/kg）的分布显著改变，脑、血浆和脂肪组织中苯环己哌啶的值显著高于对照组。虽然苯环己哌啶代谢的抑制及其相对较慢的消除速率似乎是慢性乙醇处理动物中药物效应增强的原因，但不能排除药物在中枢神经系统水平的相互作用。
