Rao V M, Rao A K, Steiner R M, Burka E R, Grainger R G, Ballas S K
Radiology. 1982 Jul;144(2):291-3. doi: 10.1148/radiology.144.2.7089282.
The effects of an ionic contrast agent (meglumine iothalamate) and a nonionic contrast medium (iopamidol) on the sickling phenomenon were studied in vitro. The findings indicate that, at the same concentration of contrast agent in the blood, iopamidol causes significantly less sickling than meglumine iothalamate. This indicates that nonionic contrast agents are preferable for diagnostic studies in patients with sickle cell anemia.
在体外研究了离子型造影剂（碘他拉葡胺）和非离子型造影剂（碘帕醇）对镰变现象的影响。研究结果表明，在血液中造影剂浓度相同的情况下，碘帕醇引起的镰变明显少于碘他拉葡胺。这表明非离子型造影剂更适合用于镰状细胞贫血患者的诊断研究。
