Velaj R, Drayer B, Albright R, Fram E
Neurology. 1985 Sep;35(9):1290-8. doi: 10.1212/wnl.35.9.1290.
The neurotoxic effects in cerebral angiography of three iodinated ionic contrast media, nonionic iopamidol, 25% mannitol, and saline controls were compared in 25 rabbits. Diatrizoate sodium meglumine was the most toxic agent, followed by diatrizoate and meglumine, iothalamate meglumine, and mannitol in terms of blood-brain barrier (BBB) disruption and coupled perfusion decline. HIPDm distribution was more sensitive than trypan blue extravasation for monitoring brain dysfunction. Iopamidol and saline controls exhibited no visual BBB breakdown or alteration in regional uptake of I-125 HIPDm, confirming the safety of nonionic iopamidol as compared with presently used ionic contrast media.
在25只兔子身上比较了三种碘化离子造影剂、非离子型碘帕醇、25%甘露醇和生理盐水对照在脑血管造影中的神经毒性作用。就血脑屏障（BBB）破坏和相关灌注下降而言，泛影葡胺钠是毒性最大的药物，其次是泛影葡胺、碘他拉葡胺和甘露醇。对于监测脑功能障碍，六碘季胺酚分布比台盼蓝外渗更敏感。碘帕醇和生理盐水对照未显示出明显的血脑屏障破坏或I-125六碘季胺酚区域摄取改变，证实了与目前使用的离子型造影剂相比，非离子型碘帕醇的安全性。
