Spisani S, Dovigo L, Corazza G, Carletti R, Traniello S
Scand J Rheumatol. 1982;11(2):65-9. doi: 10.3109/03009748209098164.
The chemotaxis, phagocytic capacity and reducing activity of neutrophils derived from peripheral blood of patients with rheumatoid arthritis (RA) did not differ from those of control. However, some significant differences between neutrophils from rheumatic and healthy subjects emerged in the presence of rifamycin SV. The chemotactic response of neutrophils from patients with RA was activated by rifamycin SV, whereas cells from controls did not orient their locomotion towards the drug. Moreover, incubation of RA patient's cells with rifamycin SV in vitro depressed phagocytic and reducing activities; the same treatment on normal cells failed to alter these functions. A correlation between improvement of clinical symptoms after treatment of RA by local infiltration with rifamycin SV, observed by others, and the impairment of phagocytosis and NBT reduction, here described, was suggested.
类风湿关节炎（RA）患者外周血中性粒细胞的趋化性、吞噬能力和还原活性与对照组无差异。然而，在利福霉素SV存在的情况下，风湿性疾病患者和健康受试者的中性粒细胞之间出现了一些显著差异。利福霉素SV激活了RA患者中性粒细胞的趋化反应，而对照组细胞的运动并未朝向该药物。此外，体外将RA患者的细胞与利福霉素SV孵育会降低吞噬和还原活性；对正常细胞进行相同处理则未能改变这些功能。有人观察到，通过利福霉素SV局部浸润治疗RA后临床症状有所改善，与本文所述的吞噬作用受损和NBT还原之间存在相关性。
