Spisani S, Marangoni C, Dovigo L, Traniello S
Inflammation. 1984 Mar;8(1):45-52. doi: 10.1007/BF00918352.
Granulocyte superoxide production by different stimuli was studied in 14 patients suffering from rheumatoid arthritis, and in four cases defective O(2) generation was shown. The effect of two chemically related drugs, such as indomethacin and oxamethacin, was also evaluated, since we have previously investigated the action of antiinflammatory agents on cell locomotion. Indomethacin did not affect O(2) production, whereas oxamethacin reduced significantly superoxide generation in PMNs from all subjects tested. Moreover, the extent of the effect was dependent on the stimulant used, being larger when the activation of O(2) generating system was induced by opsonized zymosan.
对14例类风湿性关节炎患者不同刺激下粒细胞超氧化物的产生进行了研究，结果显示4例患者存在O(2)生成缺陷。由于我们之前研究过抗炎药对细胞运动的作用，因此还评估了两种化学相关药物（如吲哚美辛和奥沙美辛）的效果。吲哚美辛不影响O(2)的产生，而奥沙美辛显著降低了所有受试对象中性粒细胞中超氧化物的生成。此外，这种作用的程度取决于所使用的刺激物，当通过调理酵母聚糖诱导O(2)生成系统激活时，作用更大。
