Bump E A, Yu N Y, Brown J M
Science. 1982 Aug 6;217(4559):544-5. doi: 10.1126/science.7089580.
Depletion of glutathione in Chinese hamster ovary cells in vitro by diethyl maleate resulted in enhancement of the effect of x-rays on cell survival under hypoxic conditions but not under oxygenated conditions. Hypoxic EMT6 tumor cells were similarly sensitized in vivo. The action of diethyl maleate is synergistic with the effect of the electron-affinic radiosensitizer misonidazole, suggesting that the effectiveness of misonidazole in cancer radiotherapy may be improved by combining it with drugs that deplete intracellular glutathione.
在体外，马来酸二乙酯可使中国仓鼠卵巢细胞中的谷胱甘肽耗竭，这导致在低氧条件下X射线对细胞存活的影响增强，但在有氧条件下则不然。低氧的EMT6肿瘤细胞在体内也同样被致敏。马来酸二乙酯的作用与亲电子放射增敏剂米索硝唑的作用具有协同性，这表明将米索硝唑与消耗细胞内谷胱甘肽的药物联合使用，可能会提高其在癌症放射治疗中的有效性。
