Weise W, Lindner S, Prügel P
Zentralbl Gynakol. 1982;104(1):17-25.
Gonadotrophin treatment was given to 81 patients with functional sterility. Individualised dosage proved possible, depending on close therapeutic monitoring. General input can be rationalised along with growing experience.--WHO Group I included 7.4 per cent of the patients reviewed. The pregnancy rate of this Group was 83 per cent. WHO Group II included 90.4 per cent. Their pregnancy rate was 37 per cent. Clomiphene failure was recorded from 79 per cent of the patients. The overall pregnancy rate amounted to 39.5 per cent, even with additional presence of tubal and andrological sterility factors. Overstimulation was recordable from 18.5 per cent of the probands. Multiple pregnancy occurred to 9.4 per cent. Rates of abortion could be kept as low as 9.4 per cent by early sick leave and progesterone substitution.--Young age of patient, short time of desire of children, and hypogonadotrophic normoprolactinaemic amenorrhoea proved to be the most favourable set of indications for gonadotrophin therapy.
对81例功能性不育患者进行了促性腺激素治疗。根据密切的治疗监测，个性化给药是可行的。随着经验的增加，一般投入可以合理化。——世界卫生组织第一组包括所审查患者的7.4%。该组的妊娠率为83%。世界卫生组织第二组包括90.4%。他们的妊娠率为37%。79%的患者记录有克罗米芬治疗失败。即使存在输卵管和男性不育因素，总体妊娠率仍达39.5%。18.5%的先证者可记录到过度刺激。多胎妊娠发生率为9.4%。通过早期病假和孕激素替代，流产率可低至9.4%。——患者年龄小、渴望生育时间短以及低促性腺激素性正常催乳素血症闭经被证明是促性腺激素治疗最有利的一组适应症。
