Probst A, Ulrich J, Heitz P U
Acta Neuropathol. 1982;57(1):75-9. doi: 10.1007/BF00688880.
Two types of Alzheimer neurofibrillary tangles may be found in the hippocampus in senile dementia of the Alzheimer type. Besides classical flame-shaped intraneuronal tangles, there are less compact tangles representing extracellular remnants of destroyed neurons with neurofibrillary change. Strong immunoreactivity for glial fibrillary acidic protein (GFA) was found in the second type of tangles, which was due to penetration of fine processes of fibrous astrocytes into bundles of paired helical filaments (PHF). PHF appear to be a strong stimulus for astrocytic reaction when they are not segregated from the neuropil by the neuronal cell membrane.
在阿尔茨海默型老年痴呆症患者的海马体中，可发现两种类型的阿尔茨海默神经原纤维缠结。除了典型的火焰状神经元内缠结外，还有不太致密的缠结，代表具有神经原纤维变化的受损神经元的细胞外残余物。在第二种类型的缠结中发现了对胶质纤维酸性蛋白（GFA）的强免疫反应性，这是由于纤维性星形胶质细胞的细突起穿透到双螺旋丝（PHF）束中所致。当PHF未被神经元细胞膜与神经毡分隔开时，它们似乎是星形细胞反应的强烈刺激因素。
