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造影剂诱导的下肢血管舒张反应。I. 犬类模型。

Vasodilator response in the lower extremity induced by contrast medium. I Canine model.

作者信息

Link D P, Lantz B M

出版信息

Acta Radiol Diagn (Stockh). 1982;23(2):81-6. doi: 10.1177/028418518202300201.

DOI:10.1177/028418518202300201
PMID:7090855
Abstract

The vasodilator response induced by injections of contrast medium was observed in 11 dogs by electromagnetic flow technique. The experiments were performed to further understand video dilution technique (VDT) measurements in patients with arterial obstructive disease. Responses were observed with regard to the contrast dose relationship, time to peak flow, and abnormal flow produced up to 4 ml caused increasing magnitude of peak flow. The time to peak flow was relatively constant for all doses. Mechanical constrictions depressed th peak flow magnitude but did not affect the time to peak. Emboli produced both depression of the flow magnitude and a delay in time to peak flow. The data suggest that the VDT vasodilatory response curves obtained in patients should correlate with the degree of obstructive disease and delay in the peak flow implies outflow disease.

摘要

通过电磁血流技术在11只狗身上观察了注射造影剂引起的血管舒张反应。进行这些实验是为了进一步了解动脉阻塞性疾病患者的视频稀释技术(VDT)测量。观察了对比剂剂量关系、血流峰值时间以及注入高达4毫升造影剂时产生的异常血流所引起的峰值血流增加幅度。所有剂量下的血流峰值时间相对恒定。机械性狭窄降低了峰值血流幅度,但不影响血流峰值时间。栓子既降低了血流幅度,又延迟了血流峰值时间。数据表明,在患者中获得的VDT血管舒张反应曲线应与阻塞性疾病的程度相关,而血流峰值延迟意味着流出道疾病。

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