Tátrai E, Timár M, Sass P, Adamis Z, Ungváry G
Acta Morphol Acad Sci Hung. 1982;30(1):79-87.
Male CFY rats were injected into their trachea with a suspension of dust of ore mine dead rock of high quartz content and mixed composition (particle size: 0-60 micrometers). Three and six months after treatment, foreign body granulation and after twelve months a non-fibrotic diffuse lung disease was seen in the animals. After twelve months of exposure, non-specific, mature sinus histiocytosis and small focal epitheloid cell reaction were found to develop in the cervical, lung-hilar and retroperitoneal lymph nodes. The histopathological changes were compared with those seen in experimental silicosis induced by DQ12 quartz. It is concluded that the hazardous effect of industrial dusts is not identical with their fibrogenic effect.
将高石英含量且成分混合（粒径：0 - 60微米）的矿山废石粉尘悬浮液注入雄性CFY大鼠的气管。处理后3个月和6个月时，在动物体内观察到异物肉芽肿，12个月后出现非纤维化弥漫性肺病。暴露12个月后，发现颈部、肺门和腹膜后淋巴结出现非特异性、成熟的窦组织细胞增生和小灶性上皮样细胞反应。将这些组织病理学变化与DQ12石英诱发的实验性矽肺中的变化进行比较。得出的结论是，工业粉尘的有害作用与其致纤维化作用并不相同。
