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系统性红斑狼疮患者免疫复合物对单核细胞的激活作用。

Monocyte activation by immune complexes of patients with SLE.

作者信息

Kávai M, Zsindely A, Sonkoly I, Bányai A, Szegedi G

出版信息

Adv Exp Med Biol. 1982;141:575-82. doi: 10.1007/978-1-4684-8088-7_56.

DOI:10.1007/978-1-4684-8088-7_56
PMID:7090928
Abstract
  1. IC precipitated by PEG from patients with SLE inhibit in vitro the FcR dependent reaction of normal monocytes with sSRBC, while the C3bR dependent reaction of the cells with sensitized yeast is reduced only by some of them. The monocytes were preincubated with the IC for 30 min at room temperature. 2. When the monocytes were incubated with the IC for 22 hours at 37 degrees C the reaction of FcR with sSRBC increased, while the C3bR dependent reaction did not altered. 3. Simultaneously with the increasing FcR dependent reaction, the secretion of lysosomal beta-glucuronidase of monocytes cultivated with IC is greater than those of the controls.
摘要
  1. 用聚乙二醇(PEG)从系统性红斑狼疮(SLE)患者体内沉淀出的免疫复合物(IC),在体外可抑制正常单核细胞与绵羊红细胞(sSRBC)的Fc受体依赖性反应,而细胞与致敏酵母的C3b受体依赖性反应仅被其中一些IC所降低。单核细胞在室温下与IC预孵育30分钟。2. 当单核细胞在37℃下与IC孵育22小时时,Fc受体与sSRBC的反应增强,而C3b受体依赖性反应未改变。3. 与Fc受体依赖性反应增强同时,用IC培养的单核细胞溶酶体β-葡萄糖醛酸酶的分泌量大于对照组。

相似文献

1
Monocyte activation by immune complexes of patients with SLE.系统性红斑狼疮患者免疫复合物对单核细胞的激活作用。
Adv Exp Med Biol. 1982;141:575-82. doi: 10.1007/978-1-4684-8088-7_56.
2
Signals of monocyte activation in patients with SLE.系统性红斑狼疮患者单核细胞激活的信号。
Clin Exp Immunol. 1983 Feb;51(2):255-60.
3
Defective immune complex degradation by monocytes in patients with systemic lupus erythematosus.系统性红斑狼疮患者单核细胞对免疫复合物的降解存在缺陷。
Scand J Immunol. 1986 Nov;24(5):527-32. doi: 10.1111/j.1365-3083.1986.tb02167.x.
4
Defective mononuclear phagocyte function in systemic lupus erythematosus: dissociation of Fc receptor-ligand binding and internalization.系统性红斑狼疮中单核吞噬细胞功能缺陷:Fc受体-配体结合与内化的解离
J Immunol. 1984 Nov;133(5):2525-31.
5
Enhanced Fc receptor function of monocytes from patients with clinically active systemic lupus erythematosus: binding and degradation of soluble immune complexes in vitro.临床活动期系统性红斑狼疮患者单核细胞的Fc受体功能增强:体外可溶性免疫复合物的结合与降解
Jpn J Med. 1986 Aug;25(3):263-9. doi: 10.2169/internalmedicine1962.25.263.
6
Loss of monocyte membrane receptors in patients with SLE.系统性红斑狼疮患者单核细胞膜受体的丧失
Clin Exp Immunol. 1980 Apr;40(1):66-71.
7
Evidence for intrinsic cellular defects of 'complement' receptor-mediated phagocytosis in patients with systemic lupus erythematosus (SLE).系统性红斑狼疮(SLE)患者中“补体”受体介导的吞噬作用存在内在细胞缺陷的证据。
Clin Exp Immunol. 1984 Feb;55(2):303-12.
8
Effects of immune complexes from SLE patients on human monocyte locomotion and Fc receptor function.系统性红斑狼疮患者免疫复合物对人单核细胞运动及Fc受体功能的影响。
Ann Rheum Dis. 1984 Oct;43(5):729-33. doi: 10.1136/ard.43.5.729.
9
Immune complex clearance by monocytes and macrophages in systemic lupus erythematosus.系统性红斑狼疮中单核细胞和巨噬细胞对免疫复合物的清除作用。
Autoimmun Rev. 2007 Aug;6(7):497-502. doi: 10.1016/j.autrev.2007.01.017. Epub 2007 Mar 26.
10
Monocyte lysosomal enzyme release in response to naturally occurring circulating immune complexes.单核细胞溶酶体酶对天然存在的循环免疫复合物的反应性释放。
Scand J Immunol. 1984 Feb;19(2):159-64. doi: 10.1111/j.1365-3083.1984.tb00912.x.

引用本文的文献

1
Increased expression of human T-cell immunoglobulin- and mucin-domain-containing molecule-4 in peripheral blood mononuclear cells from patients with system lupus erythematosus.红斑狼疮患者外周血单个核细胞中人 T 细胞免疫球蛋白和粘蛋白结构域分子 4 的表达增加。
Cell Mol Immunol. 2010 Mar;7(2):152-6. doi: 10.1038/cmi.2009.118. Epub 2010 Feb 8.
2
Signals of monocyte activation in patients with SLE.系统性红斑狼疮患者单核细胞激活的信号。
Clin Exp Immunol. 1983 Feb;51(2):255-60.