Petrunov B, Todorov D, Donchev P
Zh Mikrobiol Epidemiol Immunobiol. 1977 Jun(6):104-8.
The results of studying allergy to domestic dust in 168 patients suffering from bronchial asthma are presented. The diagnosis was made by means of the domestic dust allergen (10000 PNU), fraction E extracted from the whole allergen by Berrens and Young's method, and with lyophilized extract from D. pteronussinus, farinae and Glycyphagus ticks isolated from domestic dust by Voohorst and Spieksma's method. In parallel, IgE was determined in the blood serum of the patients under study by the radio-allergo-sorbent test; IgG was also determined. Microticks proved to be not the only factor determining the activity of domestic dust. Results of diagnosis in vivo and in vitro were found to correlate. The authors believe that the activity of domestic dust allergen formed on account of the reactions of the Maillard's type, in which a significant role was played by the "lysine-sugar) compounds.
本文展示了对168例支气管哮喘患者进行室内灰尘过敏研究的结果。诊断采用室内灰尘过敏原（10000 PNU）、通过贝伦斯和扬氏方法从全过敏原中提取的E组分，以及通过沃霍斯特和斯皮克斯马氏方法从室内灰尘中分离出的粉螨、粉尘螨和嗜卷书虱的冻干提取物。同时，通过放射变应原吸附试验测定了所研究患者血清中的IgE；还测定了IgG。微小蜱虫并非决定室内灰尘活性的唯一因素。体内和体外诊断结果具有相关性。作者认为，由于美拉德反应类型形成的室内灰尘过敏原的活性，其中“赖氨酸 - 糖”化合物起了重要作用。
