McQueen D M, Peskin C S, Yellin E L
Am J Physiol. 1982 Jun;242(6):H1095-110. doi: 10.1152/ajpheart.1982.242.6.H1095.
This paper presents a computational method that can be used to study the fluid computational method that can be used to study the fluid dynamics of the natural or prosthetic mitral valve in a computer test chamber with contractile muscular walls that model the left side of the heart. Having solved the equations of motion and predicted the performance of the valve, the computer presents the results in terms of flow patterns (streamlines), pressure-contour plots, and graphs of velocity, pressure, flow, tension, and distance as functions of time. Predicted echocardiograms and phonocardiograms are also generated by the computer. These predictions are compared with the results of animal experiments, and the method is used to study the diastolic role of the chordae tendineae, the pathophysiology of mitral valve prolapse syndrome, and the fluid dynamics of pivoting disc valves. Our results support the hypothesis that the chordae have a functional role during diastole. The results also establish a computer model of mitral prolapse, which should be useful in functional studies of that condition, and show that the position of the pivot point and the curvature of the occluder can have a profound effect on the angle of opening of pivoting disc valves. These studies illustrate the applications of the method in physiology, pathophysiology, and prosthetic valve design.
本文提出了一种计算方法，该方法可用于在具有模拟心脏左侧的收缩性肌肉壁的计算机测试腔中研究天然或人工二尖瓣的流体动力学。在求解了运动方程并预测了瓣膜的性能后，计算机以流动模式（流线）、压力等高线图以及速度、压力、流量、张力和距离随时间变化的图表形式呈现结果。计算机还生成预测的超声心动图和心音图。将这些预测结果与动物实验结果进行比较，并使用该方法研究腱索在舒张期的作用、二尖瓣脱垂综合征的病理生理学以及枢轴盘瓣的流体动力学。我们的结果支持腱索在舒张期具有功能作用这一假说。研究结果还建立了二尖瓣脱垂的计算机模型，该模型在对该病症的功能研究中应会有用，并且表明枢轴点的位置和封堵器的曲率对枢轴盘瓣的开口角度可能有深远影响。这些研究说明了该方法在生理学、病理生理学和人工瓣膜设计中的应用。
