Stene J K, Burns B, Permutt S, Caldini P, Shanoff M
Am J Physiol. 1982 Jul;243(1):R152-8. doi: 10.1152/ajpregu.1982.243.1.R152.
Occlusion of the thoracic aorta (AO) in dogs with a constant volume right ventricular extracorporeal bypass increased cardiac output (Q) by 43% and mean arterial pressure by 46%, while mean systemic pressure (MSP) was unchanged. We compared AO with occlusion of the brachiocephalic and left subclavian arteries (BSO) which decreased cardiac output by 5%, increased mean arterial pressure by 32%, and increased MSP by 11%. We feel these results confirm that AO elevates preload by transferring blood volume from the splanchnic veins to the vascular system drained by the superior vena cava. If the heart is competent to keep right arterial pressure at or near zero, this increase in preload will elevate Q above control levels. Comparing our data with results of other authors who have not controlled right atrial pressure, emphasizes the importance of a competent right ventricle in allowing venous return to determine Q.
在进行恒容右心室体外循环的犬中，阻断胸主动脉可使心输出量（Q）增加43%，平均动脉压增加46%，而平均体循环压力（MSP）不变。我们将胸主动脉阻断与头臂动脉和左锁骨下动脉阻断（BSO）进行了比较，后者使心输出量降低5%，平均动脉压升高32%，MSP升高11%。我们认为这些结果证实，胸主动脉阻断通过将血容量从内脏静脉转移至上腔静脉引流的血管系统来增加前负荷。如果心脏能够将右心房压力维持在或接近零水平，那么这种前负荷的增加将使心输出量高于对照水平。将我们的数据与未控制右心房压力的其他作者的结果进行比较，强调了功能正常的右心室对于使静脉回流血量决定心输出量的重要性。
