Mochizuki Y, Go T, Ohkubo H, Tatara T, Motomura T
Brain Dev. 1982;4(2):127-36.
BAEP has been found to be useful for assessment of subcortical maturation. However, the precise maturational changes of the peripheral and central transmission in normal human subjects are still open to controversy. We obtained a total of 200 BAEPs from 165 normal human subjects ranging from infants to young adults. Electrodes were placed at both mastoids and the reference at the vertex. 85 dB SL click stimuli were presented binaurally at a rate of 13/sec and 2,048 responses were summated on line with an averager. Investigation of the maturation of the transmission time indicated that the peripheral auditory apparatus attains functional maturity during the first 2 months of life, whereas the central transmission time shortens up to the age of 5 to 8 years. III-II and V-IV interpeak latencies (IPLs) showed maturational changes similar to those of V-I IPLs, in contrast II-I and IV-III showed little changes. A clear increase of the amplitude of peak V up to 4 years of age and a subsequent decreasing tendency was observed. The V-I IPLs of males were longer than those of females in each age group. Females also displayed larger BAEPs for wave V than males after 2 years of age. These data indicate that it is worthwhile to have separate latency and amplitude norms for males and females from infants to adults for attaching diagnostic significance to BAEP measures.
脑干听觉诱发电位（BAEP）已被证明对评估皮层下成熟度有用。然而，正常人类受试者外周和中枢传导的确切成熟变化仍存在争议。我们从165名从婴儿到青年的正常人类受试者中总共获取了200份BAEP。电极置于双侧乳突，参考电极置于头顶。以13次/秒的速率双耳呈现85分贝声强级的短声刺激，并使用平均器在线累加2048次反应。对传导时间成熟度的研究表明，外周听觉器官在生命的头2个月内达到功能成熟，而中枢传导时间在5至8岁时缩短。III - II和V - IV峰间潜伏期（IPL）显示出与V - I IPL相似的成熟变化，相比之下，II - I和IV - III变化不大。观察到V波峰值幅度在4岁前明显增加，随后呈下降趋势。在每个年龄组中，男性的V - I IPL比女性长。2岁后，女性V波的BAEP也比男性大。这些数据表明，从婴儿到成人，为男性和女性制定单独的潜伏期和幅度标准对于赋予BAEP测量诊断意义是值得的。
