Scaioli Vidmer, Brinciotti Mario, Di Capua Matteo, Lori Silvia, Janes Augusta, Pastorino Giancarlo, Peruzzi Cinzia, Sergi Paola, Suppiej Agnese
Fondazione IRCCS Istituto Nazionale Neurologico C. Besta, Milan.
Open Neurol J. 2009 Oct 9;3:72-84. doi: 10.2174/1874205X00903010072.
The influence of physiological and methodological factors on recordings of brainstem auditory evoked potentials (BAEPs) is greater in children than in adults.
To collect and evaluate BAEP data in normal children, and measure intra- and inter-laboratory variability.
Seven hundred and fifty unselected BAEP recordings were collected and evaluated from children ranging from neonates to 14-year-olds by eight laboratories in Italy.
In newborns, three laboratories showed satisfactory concordance; wave I was more broadly distributed than wave V and IPL I-V. The evaluation of pooled BAEP data from the older children showed that laboratories with age-matched data gave overlapping results; those with unmatched-age data differed significantly. The sound intensities of the laboratories did not significantly affect absolute BAEP latencies or IPLs. Females had shorter latencies than males; the difference was not significant. A single exponential regression model was an adequate but not the best predictor of normal data.
The pooled data were consistent with the physiological maturation of the brainstem acoustic pathway. The BAEPs was reliably normalised using the natural logarithm of age. The differences between Centres were related to sample size, measurement accuracy, and inclusion and selection criteria.
The creation of multicentre common database from an unmatched data collection is feasible and reliable enough for clinical diagnosis and multicentre clinical research.
生理和方法学因素对儿童脑干听觉诱发电位（BAEP）记录的影响比成人更大。
收集和评估正常儿童的BAEP数据，并测量实验室内和实验室间的变异性。
意大利的八个实验室收集并评估了750例从新生儿到14岁儿童未经筛选的BAEP记录。
在新生儿中，三个实验室显示出令人满意的一致性；波I的分布比波V和波I-V的峰间期更广泛。对年龄较大儿童的汇总BAEP数据评估表明，具有年龄匹配数据的实验室给出了重叠的结果；那些具有不匹配年龄数据的实验室差异显著。实验室的声音强度对绝对BAEP潜伏期或峰间期没有显著影响。女性的潜伏期比男性短；差异不显著。单指数回归模型是正常数据的一个适当但不是最佳的预测指标。
汇总数据与脑干听觉通路的生理成熟一致。使用年龄的自然对数可可靠地标准化BAEP。各中心之间的差异与样本量、测量准确性以及纳入和选择标准有关。
从不匹配的数据收集中创建多中心通用数据库对于临床诊断和多中心临床研究是可行且足够可靠的。
