长时间持续输注硫喷妥钠期间的血浆和脑脊液巴比妥酸盐水平

Plasma and cerebrospinal fluid barbiturate levels during prolonged continuous thiopentone infusion.

作者信息

Airey I L, Smith P A, Stoddart J C

出版信息

Anaesthesia. 1982 Mar;37(3):328-31. doi: 10.1111/j.1365-2044.1982.tb01110.x.

DOI:10.1111/j.1365-2044.1982.tb01110.x

Abstract

During an infusion of thiopentone to control status epilepticus secondary to hypoxic brain damage, thiopentone and pentobarbitone levels were measured in the serum and cerebrospinal fluid (CSF). Pentobarbitone was found to be present in the serum between 7.8 and 11.1% of the thiopentone levels. There was a prompt response in serum levels of thiopentone to changes in the infusion rate. The CSF thiopentone varied between 15 and 40% of the serum levels. The CSF anticonvulsant threshold for thiopentone for this patient was between 5 and 15 mg/litre.

摘要

在输注硫喷妥钠以控制继发于缺氧性脑损伤的癫痫持续状态期间，对血清和脑脊液（CSF）中的硫喷妥钠和戊巴比妥水平进行了测量。发现血清中戊巴比妥的含量为硫喷妥钠水平的7.8%至11.1%。硫喷妥钠的血清水平对输注速率的变化有迅速反应。脑脊液中硫喷妥钠的含量为血清水平的15%至40%。该患者硫喷妥钠的脑脊液抗惊厥阈值在5至15毫克/升之间。