Todd J K
Ann Intern Med. 1982 Jun;96(6 Pt 2):839-42. doi: 10.7326/0003-4819-96-6-839.
Toxic shock syndrome associated with Staphylococcus aureus was first described in 1978, although cases of patients with similar findings were reported as far back as 1927. Various strict clinical definitions for toxic shock syndrome have been proposed that still should include exclusionary data (titers, cultures) when possible. Epidemiologic studies of toxic shock syndrome confirm that it occurs in males and nonmenstruating females, but more commonly in menstruating females, especially those using tampons. Microbiologic studies have identified phenotypic characteristics of S. aureus strains associated with toxic shock syndrome but none have been shown to be causally related. The attentiveness of the lay press to toxic shock syndrome research should not divert investigators from an orderly scientific process and appropriate critical review.
1978年首次描述了与金黄色葡萄球菌相关的中毒性休克综合征，尽管早在1927年就有报告称患者有类似症状。针对中毒性休克综合征提出了各种严格的临床定义，在可能的情况下仍应包括排除性数据（滴度、培养）。中毒性休克综合征的流行病学研究证实，该疾病在男性和非经期女性中都有发生，但更常见于经期女性，尤其是使用卫生棉条的女性。微生物学研究已经确定了与中毒性休克综合征相关的金黄色葡萄球菌菌株的表型特征，但尚未证明有任何特征存在因果关系。大众媒体对中毒性休克综合征研究的关注不应使研究人员偏离有序的科学进程和适当的批判性审查。
