Ross S, Arffa R, Miller D, Weiss J N, Ransil B J
Ann Ophthalmol. 1982 Mar;14(3):245-9.
Clinical vitreous fluorophotometry is a technique used to evaluate the early breakdown of the blood-retina barrier, which is often seen in diabetic retinopathy. However, the test does not take into account the possibility of individual variations of fluorescein diffusion in the vitreous body. This study undertook to follow the diffusion of a fluorescein solution in 20 different bovine vitreous bodies in a laboratory setting. The results showed a broad distribution of fluorescein diffusion in the sampled population. By statistical analysis, at least three subgroups, differing with respect to the fluorescein dye diffusion pattern, were identified. Further experiments suggest that variation in hyaluronic acid structure in vitreous bodies might account for these differences.
临床玻璃体荧光光度测定法是一种用于评估血视网膜屏障早期破坏的技术，这种情况在糖尿病性视网膜病变中很常见。然而，该测试没有考虑到荧光素在玻璃体内扩散的个体差异可能性。本研究试图在实验室环境中追踪荧光素溶液在20个不同牛玻璃体中的扩散情况。结果显示，在抽样群体中荧光素扩散分布广泛。通过统计分析，确定了至少三个在荧光素染料扩散模式方面存在差异的亚组。进一步的实验表明，玻璃体内透明质酸结构的变化可能是造成这些差异的原因。
