Sorokin E L, Smoliakova G P
Filial of MNTK "Microsurgery of Eye", Khabarovsk.
Vestn Oftalmol. 1997 Mar-Apr;113(2):16-9.
Transcapillary metabolism of the retina and effects of triglycerides on the transcapillary function of the retina in diabetes mellitus were examined in 79 patients (mean age 45.4 +/- 3 years) with various stages of diabetic retinopathy (DR) by fluorometry of the vitreous body. The filtration in the blood-retina direction was 1.2-1.3 times higher than in the control as early as during the functional and preclinical stages of DR, and the coefficient of fluorescein withdrawal from the vitreous body was 4.5 to 6.2% decreased. As DR progressed, the permeability of the blood-retinal barrier in the blood-retina direction increased and the discharge from the retina to the blood was decelerated, which was confirmed by a progressive prolongation of diffusion of 0.1 ml of 1% fluorescein solution injected subconjunctivally: from 1.3 +/- 0.2 and 1.4 +/- 0.5 h in the functional and preclinical stages, respectively, to 2.7 +/- 0.3 h in the proliferative stage of DR versus 1.05 +/- 0.01 h in the control. The level of serum triglycerides and coefficients of fluorescein entry in and withdrawal from the vitreous body, time of papule diffusion, and vascular changes in the microcirculatory vessels reliably correlated.
通过玻璃体荧光测定法，对79例（平均年龄45.4±3岁）患有不同阶段糖尿病视网膜病变（DR）的患者，研究了视网膜的跨毛细血管代谢以及甘油三酯对糖尿病患者视网膜跨毛细血管功能的影响。早在DR的功能和临床前期阶段，血液-视网膜方向的滤过就比对照组高1.2-1.3倍，并且从玻璃体中提取荧光素的系数降低了4.5%至6.2%。随着DR的进展，血液-视网膜方向的血-视网膜屏障通透性增加，视网膜向血液的排出减慢，这通过结膜下注射0.1 ml 1%荧光素溶液的扩散逐渐延长得到证实：在功能和临床前期阶段分别为1.3±0.2小时和1.4±0.5小时，在DR增殖期为2.7±0.3小时，而对照组为1.05±0.01小时。血清甘油三酯水平、荧光素进入和退出玻璃体的系数、丘疹扩散时间以及微循环血管中的血管变化之间存在可靠的相关性。
