囊性纤维化患者从婴儿期到学龄期的肺功能
Lung function from infancy to school age in cystic fibrosis.
作者信息
Beardsmore C S
机构信息
Department of Child Health, University of Leicester, Leicester Royal Infirmary.
出版信息
Arch Dis Child. 1995 Dec;73(6):519-23. doi: 10.1136/adc.73.6.519.
Abstract
The aim was to investigate pulmonary mechanics in patients with cystic fibrosis during infancy and again in early childhood to see whether infant tests predicted status at school age. Plethysmographic measurements of thoracic gas volume and airways resistance were made in 29 patients at 6 months and again at 5 years 10 months. Maximum flow at functional residual capacity was measured during infancy for comparison with maximum expiratory flow rates during childhood. While many patients had normal measurements during infancy, pulmonary function had deteriorated by school age. Thoracic gas volume at school age was significantly related to the values in infancy, but other measurements made during childhood were independent of infant values. The relations between measurements in infancy and early childhood described here provide a background against which the role of external factors on pulmonary function in young children with cystic fibrosis can be investigated.
摘要
目的是研究囊性纤维化患者在婴儿期和幼儿期的肺力学，以观察婴儿期的检测结果能否预测学龄期的状况。对29名患者在6个月大时和5岁10个月时进行了胸腔气体容积和气道阻力的体积描记测量。在婴儿期测量了功能残气量时的最大流速，以便与儿童期的最大呼气流量率进行比较。虽然许多患者在婴儿期测量结果正常，但到学龄期肺功能已恶化。学龄期的胸腔气体容积与婴儿期的值显著相关，但儿童期进行的其他测量结果与婴儿期的值无关。这里描述的婴儿期和幼儿期测量结果之间的关系为研究外部因素对患有囊性纤维化的幼儿肺功能的作用提供了背景。
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