囊性纤维化患者从婴儿期到学龄期的肺功能
Lung function from infancy to school age in cystic fibrosis.
作者信息
Beardsmore C S
机构信息
Department of Child Health, University of Leicester, Leicester Royal Infirmary.
出版信息
Arch Dis Child. 1995 Dec;73(6):519-23. doi: 10.1136/adc.73.6.519.
Abstract
The aim was to investigate pulmonary mechanics in patients with cystic fibrosis during infancy and again in early childhood to see whether infant tests predicted status at school age. Plethysmographic measurements of thoracic gas volume and airways resistance were made in 29 patients at 6 months and again at 5 years 10 months. Maximum flow at functional residual capacity was measured during infancy for comparison with maximum expiratory flow rates during childhood. While many patients had normal measurements during infancy, pulmonary function had deteriorated by school age. Thoracic gas volume at school age was significantly related to the values in infancy, but other measurements made during childhood were independent of infant values. The relations between measurements in infancy and early childhood described here provide a background against which the role of external factors on pulmonary function in young children with cystic fibrosis can be investigated.
摘要
目的是研究囊性纤维化患者在婴儿期和幼儿期的肺力学，以观察婴儿期的检测结果能否预测学龄期的状况。对29名患者在6个月大时和5岁10个月时进行了胸腔气体容积和气道阻力的体积描记测量。在婴儿期测量了功能残气量时的最大流速，以便与儿童期的最大呼气流量率进行比较。虽然许多患者在婴儿期测量结果正常，但到学龄期肺功能已恶化。学龄期的胸腔气体容积与婴儿期的值显著相关，但儿童期进行的其他测量结果与婴儿期的值无关。这里描述的婴儿期和幼儿期测量结果之间的关系为研究外部因素对患有囊性纤维化的幼儿肺功能的作用提供了背景。
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本文引用的文献
1
A rapid plethysmographic method for measuring thoracic gas volume: a comparison with a nitrogen washout method for measuring functional residual capacity in normal subjects.一种测量胸内气体容积的快速体积描记法：与氮洗出法测量正常受试者功能残气量的比较
J Clin Invest. 1956 Mar;35(3):322-6. doi: 10.1172/JCI103281.
2
Cystic fibrosis identified by neonatal screening: incidence, genotype, and early natural history.通过新生儿筛查确诊的囊性纤维化：发病率、基因型及早期自然病史
Arch Dis Child. 1993 Apr;68(4):464-7. doi: 10.1136/adc.68.4.464.
3
Efficacy and safety of short-term administration of aerosolized recombinant human deoxyribonuclease in patients with cystic fibrosis.雾化吸入重组人脱氧核糖核酸酶短期给药对囊性纤维化患者的疗效和安全性
Am Rev Respir Dis. 1993 Jul;148(1):145-51. doi: 10.1164/ajrccm/148.1.145.
4
Predictive value of pulmonary function testing during pulmonary exacerbations in cystic fibrosis.
Pediatr Pulmonol. 1993 Oct;16(4):227-35. doi: 10.1002/ppul.1950160404.
5
Evolution of pulmonary function during an acute exacerbation in hospitalized patients with cystic fibrosis.住院囊性纤维化患者急性加重期肺功能的演变
Pediatr Pulmonol. 1993 Dec;16(6):347-53. doi: 10.1002/ppul.1950160605.
6
Prognosis in cystic fibrosis treated with continuous flucloxacillin from the neonatal period.从新生儿期开始用氟氯西林持续治疗囊性纤维化的预后。
Arch Dis Child. 1994 Feb;70(2):84-9. doi: 10.1136/adc.70.2.84.
7
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8
9
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J Appl Physiol Respir Environ Exerc Physiol. 1982 Nov;53(5):1220-7. doi: 10.1152/jappl.1982.53.5.1220.
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