Kendler K S, Hays P
Arch Gen Psychiatry. 1982 Jun;39(6):643-7. doi: 10.1001/archpsyc.1982.04290060005002.
This study examines whether the presence of premorbid inferiority feelings (PIFs) defines a distinct subgroup of schizophrenia. Of 122 clinically diagnosed schizophrenics, 93% of whom met DSM-III criteria for schizophrenic disorder, 31 were found to have PIFs. By family history, schizophrenia was significantly less common in first-degree relatives of schizophrenics with (1.5%) than without (9.1%) PIFs, while affective disorders were equally common in both groups of relatives. Compared with schizophrenics without PIFs, schizophrenics with PIFs were significantly more likely to have been in a stressful environment at the onset of their disorder, to have an embarrassing physical handicap, to be less severely thought-disordered, and to have a lower rate of relapse on follow-up. From a genetic, etiologic, symptomatic, and prognostic perspective, the presence of PIFs may define a distinct subgroup of schizophrenia.
本研究探讨病前自卑情绪（PIFs）的存在是否可界定精神分裂症的一个独特亚组。在122例临床诊断的精神分裂症患者中（其中93%符合精神分裂症障碍的DSM - III标准），发现31例有病前自卑情绪。通过家族史研究发现，有病前自卑情绪的精神分裂症患者的一级亲属中患精神分裂症的比例（1.5%）显著低于无病前自卑情绪者（9.1%），而情感障碍在两组亲属中的发生率相当。与无病前自卑情绪的精神分裂症患者相比，有病前自卑情绪的患者在发病时处于应激环境、有令人尴尬的身体残疾的可能性显著更高，思维紊乱程度较轻，随访时复发率较低。从遗传、病因、症状和预后角度来看，病前自卑情绪的存在可能界定了精神分裂症的一个独特亚组。
