Werneck L C
Arq Neuropsiquiatr. 1982 Mar;40(1):67-76. doi: 10.1590/s0004-282x1982000100007.
A study of 17 muscle biopsies from patients with myasthenia gravis was done, using freshfrozen section and histochemistry tecnics. It was found 15 abnormal muscle biopsies. The most common abnormality were small dark angular fibers, excess of lipids droplets outside the muscle membrane, changes in fiber size and type II fiber atrophy. These findings suggested denervation in 11 biopsies, type II fiber atrophy in 7, linfocyte infiltration in 4, fiber necrosis with fagocitosis in 1 and 2 were normal. Was noted a direct correlation between the disease duration and the severity of the histological abnormality. Two patients had tymoma. Congenital myasthenia gravis, rheumatoid arthritis, intersticial hypertrophic neuritis, Hashimoto tireoiditis and concomitance of myasthenic syndrome was found once in different patients.
对17例重症肌无力患者的肌肉活检进行了研究，采用新鲜冰冻切片和组织化学技术。发现15例肌肉活检异常。最常见的异常是小的深色角状纤维、肌膜外脂质滴过多、纤维大小改变和II型纤维萎缩。这些发现提示11例活检存在去神经支配，7例存在II型纤维萎缩，4例有淋巴细胞浸润，1例有纤维坏死伴吞噬现象，2例正常。注意到疾病持续时间与组织学异常严重程度之间存在直接相关性。两名患者患有胸腺瘤。先天性重症肌无力、类风湿性关节炎、间质性肥厚性神经炎、桥本甲状腺炎以及肌无力综合征的合并症在不同患者中各发现1例。
