Department of Neurosurgery, The Second Affiliated Hospital of Hainan Medical University, 368 Yehai Avenue, Longhua District, Haikou City, Hainan Province, 570311, China.
Hainan Medical University, No.3 Xueyuan Road, Longhua District, Haikou City, Hainan Province, 571199, China.
BMC Neurol. 2024 Aug 12;24(1):281. doi: 10.1186/s12883-024-03663-7.
Angiostrongyliasis cantonensis is a severe yet rare parasitic infection caused by the larvae of Angiostrongylus cantonensis. The primary characteristic feature of this foodborne illness in humans is eosinophilic meningitis. Recently, there has been a gradual increase in reported cases globally. Due to the lack of typical clinical symptoms, signs, and specific laboratory tests, early diagnosis of this disease poses significant challenges. Failure to diagnose and treat this condition promptly can result in fatalities.
We present the case of a 13-year-old male patient who initially presented with fever and headache. The patient was preliminarily diagnosed with bacterial meningitis and received treatment with antibacterial drugs. However, the patient's condition worsened, and he developed progressive consciousness disturbances. Eventually, metagenomic next-generation sequencing (mNGS) testing of cerebrospinal fluid samples indicated Angiostrongylus cantonensis infection. Following treatment with albendazole and prednisone, the patient made a full recovery. We include this case report as part of a literature review to emphasize the potential applications of mNGS in the early diagnosis of Angiostrongyliasis cantonensis.
mNGS technology plays a crucial role in the diagnosis of angiostrongyliasis cantonensis. As this technology continues to evolve and be applied, we believe it will play an increasingly important role in diagnosing, treating, and monitoring angiostrongyliasis cantonensis.
广州管圆线虫病是一种由广州管圆线虫幼虫引起的严重但罕见的寄生虫感染。这种食源性疾病在人类中的主要特征是嗜酸性粒细胞性脑膜炎。近年来，全球报告的病例逐渐增加。由于缺乏典型的临床症状、体征和特定的实验室检测，早期诊断该病具有很大的挑战性。如果不能及时诊断和治疗，可能会导致死亡。
我们报告了一例 13 岁男性患者，最初表现为发热和头痛。患者被初步诊断为细菌性脑膜炎，并接受了抗菌药物治疗。然而，患者的病情恶化，出现进行性意识障碍。最终，对脑脊液样本进行宏基因组下一代测序（mNGS）检测提示广州管圆线虫感染。患者接受阿苯达唑和泼尼松治疗后完全康复。我们将此病例报告纳入文献综述，以强调 mNGS 在早期诊断广州管圆线虫病中的潜在应用。
mNGS 技术在广州管圆线虫病的诊断中发挥着重要作用。随着这项技术的不断发展和应用，我们相信它将在诊断、治疗和监测广州管圆线虫病方面发挥越来越重要的作用。
