Hultcrantz E
Acta Physiol Scand. 1979 May;106(1):29-37. doi: 10.1111/j.1748-1716.1979.tb06366.x.
The cochlear blood flow was measured with the microsphere method in unanesthetized rabbits, prior to and during noise-exposure. Different sound pressure levels were used: 100 dB, 115 dB and 120 dB. Some of the animals had the cervical sympathetic trunk cut unilaterally. The effects of the delivered noise on the organ of Corti were studied in other rabbits with scanning electron microscopy. In spite of ultrastructural changes indicating damage of sensory cells after 115 dB and 120 dB exposure no changes of the total cochlear blood flow could be observed. After unilateral section of the cervical sympathetic trunk the cochlear blood flow was less on the intact side (25%) already prior to noise exposure and the difference was not significantly affected by noise. Different sizes of microspheres were used: 8.2, 8.4, 8.7, 9,2 mum. The 8.2 and 8.4 mum-spheres seemed well fitted for measurements of cochlear blood flow but passed the cerebral capillaries to a high extent. Control experiments using both 8.2/8.4 mum-spheres and 15 mum-spheres were performed and the degree of passage in different tissues was estimated.
在未麻醉的兔子身上，于噪声暴露前及暴露期间，采用微球法测量耳蜗血流量。使用了不同的声压级：100分贝、115分贝和120分贝。部分动物单侧切断颈交感干。用扫描电子显微镜研究了其他兔子中所施加噪声对柯蒂氏器的影响。尽管在115分贝和120分贝暴露后超微结构变化表明感觉细胞受损，但未观察到耳蜗总血流量有变化。单侧切断颈交感干后，在噪声暴露前，完整侧的耳蜗血流量就已经减少（25%），且这种差异未受噪声显著影响。使用了不同大小的微球：8.2、8.4、8.7、9.2微米。8.2微米和8.4微米的微球似乎很适合测量耳蜗血流量，但很大程度上会通过脑毛细血管。使用8.2/8.4微米微球和15微米微球进行了对照实验，并估计了在不同组织中的通过程度。
