Ginzler E M, Diamond H S, Weiner M, Schlesinger M, Fries J F, Wasner C, Medsger T A, Ziegler G, Klippel J H, Hadler N M, Albert D A, Hess E V, Spencer-Green G, Grayzel A, Worth D, Hahn B H, Barnett E V
Arthritis Rheum. 1982 Jun;25(6):601-11. doi: 10.1002/art.1780250601.
A retrospective study of factors influencing survival in 1,103 patients with systemic lupus erythematosus (SLE) was carried out at 9 university centers diverse in geographic, socioeconomic, and racial characteristics. The mortality and disease characteristics of the patients at study entry varied widely among centers. The survival rates from the time patients with a diagnosis of SLE were first evaluated at the participating center was 90% at 1 year, 77% at 5 years, and 71% at 10 years. Patients with a serum creatinine greater than 3 mg/dl at study entry had the lowest survival rates: 48%, 29%, and 12% at 1, 5, and 10 years, respectively. Survival rate also correlated independently with the entry hematocrit, degree of proteinuria, number of preliminary American Rheumatism Association criteria for SLE satisfied, and source of funding of medical care. When data were corrected for socioeconomic status, race/ethnic origin did not significantly influence survival. Survival rates varied widely at different participating institutions, generally due to differences in disease severity. Place of treatment was independently associated with survival only in the second year after study entry. Disease duration before study entry did not account for the differences in disease severity.
在9个地理、社会经济和种族特征各异的大学中心，对1103例系统性红斑狼疮（SLE）患者的生存影响因素进行了一项回顾性研究。各中心研究入组时患者的死亡率和疾病特征差异很大。从参与中心首次评估诊断为SLE的患者开始计算，1年生存率为90%，5年生存率为77%，10年生存率为71%。研究入组时血清肌酐大于3mg/dl的患者生存率最低：1年、5年和10年分别为48%、29%和12%。生存率还与入组时的血细胞比容、蛋白尿程度、满足美国风湿病学会SLE初步标准的数量以及医疗资金来源独立相关。校正社会经济地位数据后，种族/族裔起源对生存率无显著影响。不同参与机构的生存率差异很大，这通常是由于疾病严重程度不同所致。治疗地点仅在研究入组后的第二年与生存率独立相关。研究入组前的疾病持续时间不能解释疾病严重程度的差异。
