水杨酸钠在术后牙痛中的疗效及药代动力学
The efficacy and pharmacokinetics of sodium salicylate in post-operative dental pain.
作者信息
Seymour R A, Rawlins M D, Clothier A
出版信息
Br J Clin Pharmacol. 1984 Feb;17(2):161-3. doi: 10.1111/j.1365-2125.1984.tb02331.x.
Abstract
Sodium salicylate, 537 mg and 1074 mg were compared in a double-blind cross-over study in 24 patients with post-operative pain following removal of impacted lower third molars. No significant analgesic effect was observed after either dose of sodium salicylate, either overall or at any time point during the 5 h investigation period. Peak plasma concentrations of salicylate after 537 mg were observed at 30 min after dosage, whereas peak plasma salicylate concentrations after 1074 mg sodium salicylate occurred at 45 min after dosage.
摘要
在一项双盲交叉研究中，对24例拔除下颌阻生第三磨牙后出现术后疼痛的患者，比较了537毫克和1074毫克水杨酸钠的效果。在5小时的研究期间，无论总体还是任何时间点，两种剂量的水杨酸钠均未观察到显著的镇痛作用。服用537毫克水杨酸钠后，在给药后30分钟观察到水杨酸盐的血浆峰值浓度，而服用1074毫克水杨酸钠后，血浆水杨酸盐峰值浓度出现在给药后45分钟。
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