Seymour R A, Williams F M, Ward A, Rawlins M D
Br J Clin Pharmacol. 1984 Jun;17(6):697-701. doi: 10.1111/j.1365-2125.1984.tb02406.x.
Aspirin 1200 mg was compared with placebo in a randomised, double-blind, crossover study in 15 patients with postoperative pain after removal of impacted lower third molars. Over a 5 h investigation period, patients reported significantly less pain (P less than 0.01) after treatment with aspirin, than after treatment with placebo. Peak concentrations of aspirin occurred at 15 min after dosage. Significant negative correlations were observed between plasma aspirin esterase activity and both AUC aspirin (r = -0.904, P less than 0.001) and AUC analgesia (r = -0.91, P less than 0.001). Similarly, a significant correlation was observed between AUC aspirin and AUC analgesia (r = 0.96, P less than 0.001). Evidence from this study would suggest that an individual's pain relief in postoperative dental pain is determined by the rate of aspirin hydrolysis to salicylate.
在一项针对15例拔除下颌阻生第三磨牙后出现术后疼痛患者的随机、双盲、交叉研究中，对1200毫克阿司匹林与安慰剂进行了比较。在5小时的研究期间，患者报告服用阿司匹林后的疼痛明显少于服用安慰剂后（P<0.01）。阿司匹林的峰值浓度在给药后15分钟出现。血浆阿司匹林酯酶活性与阿司匹林的曲线下面积（AUC阿司匹林，r = -0.904，P<0.001）和镇痛的曲线下面积（AUC镇痛，r = -0.91，P<0.001）之间均观察到显著的负相关。同样，在AUC阿司匹林和AUC镇痛之间也观察到显著相关性（r = 0.96，P<0.001）。这项研究的证据表明，个体在术后牙齿疼痛中的疼痛缓解程度由阿司匹林水解为水杨酸盐的速率决定。
