Adesiyun A A, Tatini S R
Br J Exp Pathol. 1982 Jun;63(3):330-5.
Ten (24%) of 41 cynomologus monkeys (Macaca fascicularis) showed emetic response to 2.5-20 mg/Kg of ketamine injected i.m. Reduction of the levels of ketamine to one half or less of the emetic level resulted in faster recovery from sedation yet provided adequate time for intubation and subsequent intragastric feeding of staphylococcal enterotoxin (SE) in only 6 of the 10 monkeys without emesis. The onset of the first emetic episode with ketamine was similar to that induced by staphylococcal enterotoxin A (SEA). Cynomologus monkeys showing emetic response to ketamine could still be used for SE bioassay if an experimentally determined non-emetic dose for individual monkeys is employed for sedation.
41只食蟹猴（猕猴属）中有10只（24%）对肌肉注射2.5 - 20毫克/千克氯胺酮表现出呕吐反应。将氯胺酮水平降至呕吐水平的一半或更低，可使猴子从镇静状态中更快恢复，但仅在10只无呕吐反应的猴子中的6只中，为插管及随后胃内注射葡萄球菌肠毒素（SE）提供了足够时间。氯胺酮引发首次呕吐发作的时间与葡萄球菌肠毒素A（SEA）引发的相似。如果针对个体猴子采用实验确定的无呕吐剂量进行镇静，对氯胺酮有呕吐反应的食蟹猴仍可用于SE生物测定。
