Lemeshko V V, Nikitchenko Iu V
Biokhimiia. 1982 May;47(5):752-9.
The rate of lipid peroxidation (LPO) in rat liver mitochondria induced by the Fe++ + ascorbate system was considerably reduced in 1--12-month-old rats, remained unchanged thereafter up to the 24th postnatal month and was decreased in hyperthyroid rats aged 1- and 3 months. The rate of NADPH-dependent LPO was also sharply decreased up to the 12th month of age, showing a further rise in 24-month-old animals, i. e. thus remained lower than in 1- and 3-month-old rats; under hyperthyroidism the LPO rate was increased in more highly 12-month-old animals. A reverse correlation between the level of reducibility of matrix pyridine nucleotides and the rate of enzymatic LPO in mitochondria was established. A physiological role of LPO is postulated.
铁离子加抗坏血酸系统诱导的大鼠肝线粒体脂质过氧化（LPO）速率在1至12月龄大鼠中显著降低，此后直至出生后第24个月保持不变，而在1月龄和3月龄的甲状腺功能亢进大鼠中则降低。依赖NADPH的LPO速率在12月龄前也急剧下降，在24月龄动物中进一步上升，即仍低于1月龄和3月龄大鼠；在甲状腺功能亢进状态下，12月龄以上动物的LPO速率增加。建立了线粒体基质吡啶核苷酸还原水平与酶促LPO速率之间的负相关关系。推测了LPO的生理作用。
