[Intensity of lipid peroxidation in the tissues of rats during hypokinesia].

The intensity of lipid peroxidation in the homogenates and mitochondria of the liver, heart and skeletal muscle of hypokinetic rats was measured. The primary products of lipid peroxidation, i. e., diene conjugates, were accumulated in all tissues on hypokinesia days 3, 15, and 30. The content of the final product--malonic dialdehyde--in the mitochondria increased on hypokinesia days 15 and 30. The low level of NADPH--and ascorbate-dependent lipid peroxidation in the mitochondria at early stages of hypokinesia (up to 15 days) and diene conjugates in homogenates on hypokinesia day 7 can be attributed to an activation of the protective systems of the organism against the immobilization stress. It is suggested that at early stages of hypokinesia the process of lipid peroxidation, or to be more precise lipid hydroperoxidation can be blocked.