Avtsyn A P, Pershin G N, Trager R S, Shakhlamov V A, Padeĭskaia E N
Biull Eksp Biol Med. 1982 May;93(5):76-8.
In experiments in vitro dioxidineeee was highly effective as regards all the test cultures of NAG-vibrios. The MTC ranged within 1 to 62 micrograms/ml. Bactericidal action of the drug became manifest at concentrations from 4 to 250 micrograms/ml. The derivatives of di-N-oxide quinoxaline, dioxidin and quinoxidine exerted a chemotherapeutic effect and sterilizing action in experimental NAG-infection. The action of the drugs was potentiated upon combined use with lysozyme. As far as depo-sulfanilamides are concerned, sulfalenee was little active, while sulfamonomethoxine ineffective in experimental NAG-infection.
在体外实验中，二氧喹啉对所有NAG弧菌测试培养物都具有高效性。最低抑菌浓度范围在1至62微克/毫升之间。该药物在4至250微克/毫升的浓度下表现出杀菌作用。二氮氧化物喹喔啉的衍生物、二氧喹啉和喹喔啉啶在实验性NAG感染中发挥了化疗作用和杀菌作用。这些药物与溶菌酶联合使用时作用增强。就长效磺胺而言，磺胺几乎没有活性，而磺胺间甲氧嘧啶在实验性NAG感染中无效。
