Wahlsten D
Brain Res. 1982 May 13;239(2):329-47. doi: 10.1016/0006-8993(82)90513-3.
Six inbred strains of adult mice either obtained from commercial suppliers or bred in the author's laboratory at Waterloo were assessed for size of body, brain and corpus callosum (CC) at a wide range of ages. Because almost all measures varied significantly with age, a simple regression procedure was used to minimize age effects statistically. The strains A/J, C57BL/6J and DBA/2J differed substantially in brain size and size of CC, but none of these animals ever showed severe deficits of CC fibres crossing the midsagittal plane. For these 3 strains the sizes of body, brain and CC were larger when bred at the Jackson Laboratory than at Waterloo. Two BALB/c strains obtained from different suppliers had over 30% of mice with defective CC, ranging continuously from total absence of transcortical fibres to slightly reduced CC size. For these two strains bred at Waterloo, brain sizes were larger and CC defects were much less frequent than when bred by commercial suppliers. The strain 129/J had a 71% frequency of CC defects when reared at the Jackson Laboratory but 38% defects when bred and reared at Waterloo. However, bodies of 129/J mice bred at Jackson were larger than those bred at Waterloo. These results show that relatively small differences in rearing conditions can have relatively large effects on certain aspects of brain development.
对从商业供应商处获得或在作者位于滑铁卢的实验室培育的6个近交系成年小鼠，在广泛的年龄范围内评估其身体、大脑和胼胝体（CC）的大小。由于几乎所有测量值都随年龄有显著变化，因此使用简单回归程序从统计学上最小化年龄效应。A/J、C57BL/6J和DBA/2J这三个品系在脑大小和CC大小上有显著差异，但这些动物均未出现CC纤维穿过矢状面的严重缺陷。对于这3个品系，在杰克逊实验室培育时身体、大脑和CC的大小比在滑铁卢时更大。从不同供应商获得的两个BALB/c品系有超过30%的小鼠CC存在缺陷，范围从完全没有跨皮质纤维到CC大小略有减小。对于在滑铁卢培育的这两个品系，脑大小更大，且CC缺陷比由商业供应商培育时少得多。129/J品系在杰克逊实验室饲养时CC缺陷频率为71%，但在滑铁卢培育和饲养时为38%。然而，在杰克逊培育的129/J小鼠身体比在滑铁卢培育的更大。这些结果表明，饲养条件相对较小的差异可能对大脑发育的某些方面产生相对较大的影响。
