未能检测到狼疮性脑病中淋巴细胞毒素的脑反应性。
Failure to detect brain reactivity of lymphocytotoxins in cerebral lupus.
作者信息
Pussell B A, Blyth F, Charlesworth J A
出版信息
Clin Exp Immunol. 1982 Jan;47(1):133-7.
Lymphocytotoxic activity (LCA) was examined in the sera of 29 patients with systemic lupus erythematosus (SLE), including eight with cerebral involvement. LCA was elevated in 80% of samples and was significantly higher in the group with cerebral disease (P less than 0.001). No correlations were observed between LCA and immune complexes or complement components. Sera from 10 patients (six with cerebral SLE) were absorbed with homogenates of normal human frontal cortex and liver using protein standards to control for dilutional effects. No serum sample showed selective depletion of LCA following incubation with brain homogenate. It is concluded that no single parameter, including brain absorption of LCA, is effective in monitoring disease activity in cerebral lupus.
检测了29例系统性红斑狼疮（SLE）患者血清中的淋巴细胞毒性活性（LCA），其中8例有脑部受累。80%的样本中LCA升高，脑部疾病组的LCA显著更高（P<0.001）。未观察到LCA与免疫复合物或补体成分之间的相关性。使用蛋白质标准品对10例患者（6例为脑部SLE患者）的血清进行正常人额叶皮质和肝脏匀浆吸收，以控制稀释效应。与脑匀浆孵育后，没有血清样本显示LCA有选择性消耗。结论是，包括LCA的脑吸收在内，没有单一参数可有效监测狼疮性脑病的疾病活动。
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