系统性红斑狼疮伴或不伴脑部受累时淋巴细胞毒性抗体的脑反应性
Brain reactivity of lymphocytotoxic antibodies in systemic lupus erythematosus with and without cerebral involvement.
作者信息
Bresnihan B, Oliver M, Grigor R, Hughes G R
出版信息
Clin Exp Immunol. 1977 Dec;30(3):333-7.
Abstract
A prospective clinical study of cold-reactive lymphocytotoxic antibodies in systemic lupus erythematosus has been completed. A highly significant association between serum lymphocytotoxicity and the development of cerebral manifestations was observed. While lymphocytotoxic antibodies from patients with cerebral lupus were absorbed by homogenates of human brain, those from patients who at no time had evidence of cerebral disease failed to cross-react with brain. It is suggested that subpopulations of lymphocytotoxic antibodies differ in their brain reactivity, and that one population may be causally related to the development of some of the features of cerebral lupus.
摘要
一项关于系统性红斑狼疮中冷反应性淋巴细胞毒性抗体的前瞻性临床研究已经完成。观察到血清淋巴细胞毒性与脑部表现的发展之间存在高度显著的关联。虽然来自狼疮脑病患者的淋巴细胞毒性抗体可被人脑匀浆吸收，但来自从未有过脑部疾病证据的患者的抗体则不会与脑发生交叉反应。提示淋巴细胞毒性抗体亚群在其脑反应性方面存在差异，且其中一个亚群可能与狼疮脑病某些特征的发生存在因果关系。
相似文献
1
Brain reactivity of lymphocytotoxic antibodies in systemic lupus erythematosus with and without cerebral involvement.
Clin Exp Immunol. 1977 Dec;30(3):333-7.
2
Brain-reactive lymphocytotoxic antibodies in the serum of patients with systemic lupus erythematosus.
J Clin Invest. 1976 Feb;57(2):509-16. doi: 10.1172/JCI108303.
3
[Neuropsychiatric manifestations in patients with systemic lupus erythematosus].
Schweiz Med Wochenschr. 1978 Dec 16;108(50):2007-12.
4
Relationship of lymphocytotoxic antibodies to lymphopenia and parameters of disease activity in systemic lupus erythematosus.
J Rheumatol. 1976 Jun;3(2):175-85.
5
Failure to detect brain reactivity of lymphocytotoxins in cerebral lupus.
Clin Exp Immunol. 1982 Jan;47(1):133-7.
6
Lymphocytotoxic antibodies in systemic lupus erythematosus are associated with disease activity irrespective of the presence of neuropsychiatric manifestations.
Scand J Rheumatol. 2007 Nov-Dec;36(6):442-7. doi: 10.1080/03009740701482768.
7
Human monoclonal anti-DNA antibodies react as lymphocytotoxic antibodies.
Eur J Immunol. 1985 Oct;15(10):1024-8. doi: 10.1002/eji.1830151012.
8
Lymphocytotoxic antibodies in family members of patients with systemic lupus erythematosus.
J Clin Invest. 1975 Jun;55(6):1254-8. doi: 10.1172/JCI108044.
9
Lymphocytotoxic antibodies in systemic lupus erythematosus: evidence for reactivity with i antigen.
Clin Exp Immunol. 1978 Mar;31(3):443-7.
10
Lymphocytotoxic antibodies in patients with systemic lupus erythematosus.
Clin Exp Immunol. 1974 Jun;17(2):237-43.
引用本文的文献
1
Definition of NPSLE: Does the ACR Nomenclature Still Hold?
Front Med (Lausanne). 2018 May 31;5:138. doi: 10.3389/fmed.2018.00138. eCollection 2018.
2
Integrative neuroscience approach to neuropsychiatric lupus.
Immunol Res. 2015 Dec;63(1-3):11-7. doi: 10.1007/s12026-015-8713-6.
3
The immune response and the connective tissue diseases.
Can Fam Physician. 1979 Mar;25:329-31.
4
Lymphocyte and neuronal antigens in neuropsychiatric lupus: presence of an elutable, immunoprecipitable lymphocyte/neuronal 52 kd reactivity.
Ann Rheum Dis. 1994 May;53(5):304-8. doi: 10.1136/ard.53.5.304.
5
Controversies in lupus: nervous system involvement.
Ann Rheum Dis. 1995 Mar;54(3):159-67. doi: 10.1136/ard.54.3.159.
6
Antiglycolipid autoantibody detected in the sera from systemic lupus erythematosus patients.
J Clin Invest. 1980 Dec;66(6):1437-40. doi: 10.1172/JCI109999.
7
Failure to detect brain reactivity of lymphocytotoxins in cerebral lupus.
Clin Exp Immunol. 1982 Jan;47(1):133-7.
8
Anticardiolipin antibodies: occurrence in Behçet's syndrome.
Ann Rheum Dis. 1984 Oct;43(5):746-8. doi: 10.1136/ard.43.5.746.
9
Treatment of multiple sclerosis with anti-measles cow colostrum.
Med Microbiol Immunol. 1984;173(2):87-93. doi: 10.1007/BF02124822.
10
The pathogenesis of neuropsychiatric lupus.
Can Med Assoc J. 1983 Feb 1;128(3):257-60.
本文引用的文献
1
THE AKR THYMIC ANTIGEN AND ITS DISTRIBUTION IN LEUKEMIAS AND NERVOUS TISSUES.
J Exp Med. 1964 Sep 1;120(3):413-33. doi: 10.1084/jem.120.3.413.
2
Serotyping for homotransplantation. 18. Refinement of microdroplet lymphocyte cytotoxicity test.
Transplantation. 1968 Nov;6(8):913-27. doi: 10.1097/00007890-196811000-00006.
3
Lymphocyte cytotoxic antibodies in systemic lupus erythematosus.
Nature. 1970 Mar 28;225(5239):1255-6. doi: 10.1038/2251255a0.
4
Cytotoxins in disease. Autocytotoxins in lupus.
N Engl J Med. 1970 Oct 1;283(14):724-8. doi: 10.1056/NEJM197010012831403.
5
Lymphotoxic activity in multiple sclerosis serum.
Neurology. 1971 Aug;21(8):783-93. doi: 10.1212/wnl.21.8.783.
6
7
The fourth component of complement in the cerebrospinal fluid in systemic Lupus erythematosus.
Arthritis Rheum. 1973 Jul-Aug;16(4):507-21. doi: 10.1002/art.1780160411.
8
Immunofluorescence studies on thymocytotoxic antibody from New Zealand Black mice.
J Immunol. 1974 Jan;112(1):285-92.
9
The choroid plexus in systemic lupus erythematosus.
Ann Intern Med. 1972 Jan;76(1):65-72. doi: 10.7326/0003-4819-76-1-65.
10
Natural cytotoxic autoantibody against thymocytes in NZB mice.
Clin Exp Immunol. 1972 Sep;12(1):133-52.
Zotero 插件