系统性红斑狼疮伴或不伴脑部受累时淋巴细胞毒性抗体的脑反应性
Brain reactivity of lymphocytotoxic antibodies in systemic lupus erythematosus with and without cerebral involvement.
作者信息
Bresnihan B, Oliver M, Grigor R, Hughes G R
出版信息
Clin Exp Immunol. 1977 Dec;30(3):333-7.
Abstract
A prospective clinical study of cold-reactive lymphocytotoxic antibodies in systemic lupus erythematosus has been completed. A highly significant association between serum lymphocytotoxicity and the development of cerebral manifestations was observed. While lymphocytotoxic antibodies from patients with cerebral lupus were absorbed by homogenates of human brain, those from patients who at no time had evidence of cerebral disease failed to cross-react with brain. It is suggested that subpopulations of lymphocytotoxic antibodies differ in their brain reactivity, and that one population may be causally related to the development of some of the features of cerebral lupus.
摘要
一项关于系统性红斑狼疮中冷反应性淋巴细胞毒性抗体的前瞻性临床研究已经完成。观察到血清淋巴细胞毒性与脑部表现的发展之间存在高度显著的关联。虽然来自狼疮脑病患者的淋巴细胞毒性抗体可被人脑匀浆吸收，但来自从未有过脑部疾病证据的患者的抗体则不会与脑发生交叉反应。提示淋巴细胞毒性抗体亚群在其脑反应性方面存在差异，且其中一个亚群可能与狼疮脑病某些特征的发生存在因果关系。
相似文献
1
Brain reactivity of lymphocytotoxic antibodies in systemic lupus erythematosus with and without cerebral involvement.系统性红斑狼疮伴或不伴脑部受累时淋巴细胞毒性抗体的脑反应性
Clin Exp Immunol. 1977 Dec;30(3):333-7.
2
Brain-reactive lymphocytotoxic antibodies in the serum of patients with systemic lupus erythematosus.系统性红斑狼疮患者血清中的脑反应性淋巴细胞毒性抗体。
J Clin Invest. 1976 Feb;57(2):509-16. doi: 10.1172/JCI108303.
3
[Neuropsychiatric manifestations in patients with systemic lupus erythematosus].
Schweiz Med Wochenschr. 1978 Dec 16;108(50):2007-12.
4
5
Failure to detect brain reactivity of lymphocytotoxins in cerebral lupus.未能检测到狼疮性脑病中淋巴细胞毒素的脑反应性。
Clin Exp Immunol. 1982 Jan;47(1):133-7.
6
Lymphocytotoxic antibodies in systemic lupus erythematosus are associated with disease activity irrespective of the presence of neuropsychiatric manifestations.系统性红斑狼疮中的淋巴细胞毒性抗体与疾病活动相关，无论是否存在神经精神表现。
Scand J Rheumatol. 2007 Nov-Dec;36(6):442-7. doi: 10.1080/03009740701482768.
7
Human monoclonal anti-DNA antibodies react as lymphocytotoxic antibodies.
Eur J Immunol. 1985 Oct;15(10):1024-8. doi: 10.1002/eji.1830151012.
8
Lymphocytotoxic antibodies in family members of patients with systemic lupus erythematosus.系统性红斑狼疮患者家庭成员中的淋巴细胞毒性抗体。
J Clin Invest. 1975 Jun;55(6):1254-8. doi: 10.1172/JCI108044.
9
Lymphocytotoxic antibodies in systemic lupus erythematosus: evidence for reactivity with i antigen.系统性红斑狼疮中的淋巴细胞毒性抗体：与i抗原反应性的证据。
Clin Exp Immunol. 1978 Mar;31(3):443-7.
10
Lymphocytotoxic antibodies in patients with systemic lupus erythematosus.系统性红斑狼疮患者体内的淋巴细胞毒性抗体。
Clin Exp Immunol. 1974 Jun;17(2):237-43.
引用本文的文献
1
Definition of NPSLE: Does the ACR Nomenclature Still Hold?神经精神狼疮的定义：美国风湿病学会的命名法仍适用吗？
Front Med (Lausanne). 2018 May 31;5:138. doi: 10.3389/fmed.2018.00138. eCollection 2018.
2
Integrative neuroscience approach to neuropsychiatric lupus.神经精神性狼疮的整合神经科学方法
Immunol Res. 2015 Dec;63(1-3):11-7. doi: 10.1007/s12026-015-8713-6.
3
The immune response and the connective tissue diseases.免疫反应与结缔组织病。
Can Fam Physician. 1979 Mar;25:329-31.
4
Lymphocyte and neuronal antigens in neuropsychiatric lupus: presence of an elutable, immunoprecipitable lymphocyte/neuronal 52 kd reactivity.神经精神性狼疮中的淋巴细胞和神经元抗原：可洗脱、可免疫沉淀的淋巴细胞/神经元52kd反应性的存在。
Ann Rheum Dis. 1994 May;53(5):304-8. doi: 10.1136/ard.53.5.304.
5
Controversies in lupus: nervous system involvement.狼疮的争议：神经系统受累
Ann Rheum Dis. 1995 Mar;54(3):159-67. doi: 10.1136/ard.54.3.159.
6
Antiglycolipid autoantibody detected in the sera from systemic lupus erythematosus patients.在系统性红斑狼疮患者血清中检测到抗糖脂自身抗体。
J Clin Invest. 1980 Dec;66(6):1437-40. doi: 10.1172/JCI109999.
7
Failure to detect brain reactivity of lymphocytotoxins in cerebral lupus.未能检测到狼疮性脑病中淋巴细胞毒素的脑反应性。
Clin Exp Immunol. 1982 Jan;47(1):133-7.
8
Anticardiolipin antibodies: occurrence in Behçet's syndrome.抗心磷脂抗体：在白塞病中的出现情况。
Ann Rheum Dis. 1984 Oct;43(5):746-8. doi: 10.1136/ard.43.5.746.
9
Treatment of multiple sclerosis with anti-measles cow colostrum.用抗麻疹牛初乳治疗多发性硬化症。
Med Microbiol Immunol. 1984;173(2):87-93. doi: 10.1007/BF02124822.
10
The pathogenesis of neuropsychiatric lupus.神经精神性狼疮的发病机制。
Can Med Assoc J. 1983 Feb 1;128(3):257-60.
本文引用的文献
1
THE AKR THYMIC ANTIGEN AND ITS DISTRIBUTION IN LEUKEMIAS AND NERVOUS TISSUES.AKR胸腺抗原及其在白血病和神经组织中的分布。
J Exp Med. 1964 Sep 1;120(3):413-33. doi: 10.1084/jem.120.3.413.
2
Serotyping for homotransplantation. 18. Refinement of microdroplet lymphocyte cytotoxicity test.同种移植的血清分型。18. 微滴淋巴细胞细胞毒性试验的改进。
Transplantation. 1968 Nov;6(8):913-27. doi: 10.1097/00007890-196811000-00006.
3
Lymphocyte cytotoxic antibodies in systemic lupus erythematosus.系统性红斑狼疮中的淋巴细胞细胞毒性抗体。
Nature. 1970 Mar 28;225(5239):1255-6. doi: 10.1038/2251255a0.
4
Cytotoxins in disease. Autocytotoxins in lupus.疾病中的细胞毒素。狼疮中的自身细胞毒素。
N Engl J Med. 1970 Oct 1;283(14):724-8. doi: 10.1056/NEJM197010012831403.
5
Lymphotoxic activity in multiple sclerosis serum.多发性硬化症血清中的淋巴细胞毒性活性。
Neurology. 1971 Aug;21(8):783-93. doi: 10.1212/wnl.21.8.783.
6
Antibodies against cell membrane constituents in systemic lupus erythematosus and related diseases. I. Cytotoxic effect of serum from patients with systemic lupus erythematosus (SLE) for allogeneic and for autologous lymphocytes.系统性红斑狼疮及相关疾病中针对细胞膜成分的抗体。I. 系统性红斑狼疮（SLE）患者血清对同种异体和自体淋巴细胞的细胞毒性作用。
Clin Exp Immunol. 1971 Apr;8(4):543-50.
7
The fourth component of complement in the cerebrospinal fluid in systemic Lupus erythematosus.系统性红斑狼疮患者脑脊液中的补体第四成分。
Arthritis Rheum. 1973 Jul-Aug;16(4):507-21. doi: 10.1002/art.1780160411.
8
Immunofluorescence studies on thymocytotoxic antibody from New Zealand Black mice.对来自新西兰黑鼠的胸腺细胞毒性抗体的免疫荧光研究。
J Immunol. 1974 Jan;112(1):285-92.
9
The choroid plexus in systemic lupus erythematosus.系统性红斑狼疮中的脉络丛。
Ann Intern Med. 1972 Jan;76(1):65-72. doi: 10.7326/0003-4819-76-1-65.
10
Natural cytotoxic autoantibody against thymocytes in NZB mice.针对NZB小鼠胸腺细胞的天然细胞毒性自身抗体。
Clin Exp Immunol. 1972 Sep;12(1):133-52.
Zotero 插件