Holm-Rutili L, Perry M A, Granger D N
Am J Physiol. 1981 Aug;241(2):G143-9. doi: 10.1152/ajpgi.1981.241.2.G143.
The purpose of this study was to determine whether the ability of the stomach to autoregulate blood flow and oxygen uptake is altered by sympathetic denervation. Blood flow, oxygen extraction, local arterial pressure, and venous pressure were continuously monitored in sympathetically innervated and denervated autoperfused dog stomach preparations. As perfusion pressure was reduced in increments from 120 to 20 mmHg in innervated preparations, blood flow and oxygen uptake decreased while oxygen extraction and vascular resistance increased. Reductions in perfusion pressure in denervated preparations resulted in a decrease in blood flow, oxygen uptake, and vascular resistance, whereas oxygen extraction increased. The ability of the stomach to regulate blood flow and oxygen uptake was significantly improved after denervation, i.e., vascular resistance decreased and oxygen uptake remained relatively constant when arterial pressure was reduced. Oxygen uptake in denervated stomachs was generally higher than that in innervated stomachs. Autoregulation of gastric blood flow therefore appears to be improved by denervation. The better autoregulation observed after denervation may result either from a reduction in sympathetic tone and/or the increase in gastric oxygen demand.
本研究的目的是确定交感神经去支配是否会改变胃自动调节血流和氧摄取的能力。在有交感神经支配和去神经支配的自灌注犬胃制剂中，持续监测血流、氧摄取、局部动脉压和静脉压。在有神经支配的制剂中，随着灌注压从120 mmHg逐步降至20 mmHg，血流和氧摄取减少，而氧摄取率和血管阻力增加。去神经支配制剂中灌注压的降低导致血流、氧摄取和血管阻力降低，而氧摄取率增加。去神经支配后，胃调节血流和氧摄取的能力显著提高，即当动脉压降低时，血管阻力降低，氧摄取保持相对恒定。去神经支配胃中的氧摄取通常高于有神经支配的胃。因此，去神经支配似乎改善了胃血流的自动调节。去神经支配后观察到的更好的自动调节可能是由于交感神经张力降低和/或胃氧需求增加所致。
