Falaschi P, D'Urso R, Negri L, Rocco A, Montecucchi P C, Henschen A, Melchiorri P, Erspamer V
Endocrinology. 1982 Aug;111(2):693-5. doi: 10.1210/endo-111-2-693.
The effect of sauvagine (SAU), a frog skin peptide, on prolactin (PRL) levels was studied in vivo and in vitro. Subcutaneous administration of SAU (20 micrograms/kg) reduced plasma PRL levels in normal adult male rats and suppressed the suckling-induced rise of PRL in lactating rats even at doses of 1 and 5 micrograms/kg. Perfusion of isolated and dispersed rat pituitary cells in vitro with increasing doses of SAU (from 5 x 10(-10) to 1.7 x 10(-8)M) induced a significant dose-related decrease of PRL secretion in the eluate. These results indicate that SAU is a potent PRL inhibiting factor and that its action is exerted at the pituitary level. If SAU or a SAU-related peptide is present in the mammalian brain, it can be tentatively hypothesized that this peptide plays an important role in the control of PRL secretion.
研究了蛙皮肽 sauvagine（SAU）对催乳素（PRL）水平的体内和体外作用。皮下注射 SAU（20 微克/千克）可降低正常成年雄性大鼠的血浆 PRL 水平，即使在 1 和 5 微克/千克的剂量下，也能抑制哺乳大鼠因哺乳引起的 PRL 升高。体外以递增剂量的 SAU（从 5×10⁻¹⁰ 到 1.7×10⁻⁸M）灌注分离和分散的大鼠垂体细胞，可使洗脱液中 PRL 分泌显著剂量相关地减少。这些结果表明，SAU 是一种有效的 PRL 抑制因子，其作用在垂体水平发挥。如果 SAU 或与 SAU 相关的肽存在于哺乳动物大脑中，可以初步推测该肽在 PRL 分泌的控制中起重要作用。
