蛙皮肽（一种蛙皮肽）在体内和体外均具有强大的催乳素抑制活性。

Potent in vivo and in vitro prolactin inhibiting activity of sauvagine, a frog skin peptide.

作者信息

Falaschi P, D'Urso R, Negri L, Rocco A, Montecucchi P C, Henschen A, Melchiorri P, Erspamer V

出版信息

Endocrinology. 1982 Aug;111(2):693-5. doi: 10.1210/endo-111-2-693.

Abstract

The effect of sauvagine (SAU), a frog skin peptide, on prolactin (PRL) levels was studied in vivo and in vitro. Subcutaneous administration of SAU (20 micrograms/kg) reduced plasma PRL levels in normal adult male rats and suppressed the suckling-induced rise of PRL in lactating rats even at doses of 1 and 5 micrograms/kg. Perfusion of isolated and dispersed rat pituitary cells in vitro with increasing doses of SAU (from 5 x 10(-10) to 1.7 x 10(-8)M) induced a significant dose-related decrease of PRL secretion in the eluate. These results indicate that SAU is a potent PRL inhibiting factor and that its action is exerted at the pituitary level. If SAU or a SAU-related peptide is present in the mammalian brain, it can be tentatively hypothesized that this peptide plays an important role in the control of PRL secretion.

摘要

研究了蛙皮肽 sauvagine（SAU）对催乳素（PRL）水平的体内和体外作用。皮下注射 SAU（20 微克/千克）可降低正常成年雄性大鼠的血浆 PRL 水平，即使在 1 和 5 微克/千克的剂量下，也能抑制哺乳大鼠因哺乳引起的 PRL 升高。体外以递增剂量的 SAU（从 5×10⁻¹⁰ 到 1.7×10⁻⁸M）灌注分离和分散的大鼠垂体细胞，可使洗脱液中 PRL 分泌显著剂量相关地减少。这些结果表明，SAU 是一种有效的 PRL 抑制因子，其作用在垂体水平发挥。如果 SAU 或与 SAU 相关的肽存在于哺乳动物大脑中，可以初步推测该肽在 PRL 分泌的控制中起重要作用。