Kast A, Nishikawa J, Yabe T
Exp Pathol. 1982;21(2):123-33. doi: 10.1016/s0232-1513(82)80061-3.
The influence of Dipyridamole on acute hepatotoxicity has been studied in male SD-JCL rats doses with carbon tetrachloride. High single oral doses of Dipyridamole lowered the serum enzyme activity and reduced significantly the area % of hepatic necrosis and hydropic degeneration, but not of steatosis. Dipyridamole was effective from 1 hr before through 6 hrs after the oral administration of CCl4. Doses below 1,000 mg/kg Dipyridamole were less effective. No delay in the onset of CCl4-induced liver damages was observed. Dipyridamole was also effective when CCl4 toxicity was enhanced by isopropanol.
已在雄性SD-JCL大鼠中研究了双嘧达莫对四氯化碳所致急性肝毒性的影响。高剂量单次口服双嘧达莫可降低血清酶活性，并显著减少肝坏死和水样变性的面积百分比，但对脂肪变性无影响。双嘧达莫在口服四氯化碳前1小时至口服后6小时均有效。双嘧达莫剂量低于1000mg/kg时效果较差。未观察到四氯化碳诱导的肝损伤发作延迟。当用异丙醇增强四氯化碳毒性时，双嘧达莫也有效。
