Shah P M, Siegel K, Stille W
Infection. 1982;10(2):85-9. doi: 10.1007/BF01816730.
49 patients were given cefoxitin in combination with azlocillin, and 15 were given an aminoglycoside as well when severe bacterial infection was suspected. In 39 cases a prompt amelioration of the clinical signs of infection was observed. Of the 17 patients who died, a post-mortem was performed in seven; only in four were signs of bacterial infection present; one had tuberculosis and one had a cytomegalovirus infection. The combination therapy was well tolerated and side-effects were rare; no bleeding complications were seen. Clinical signs of possible antagonism between the two beta-lactam antibiotics were not observed.
49例患者接受头孢西丁联合阿洛西林治疗，当怀疑有严重细菌感染时，15例患者还加用了一种氨基糖苷类药物。39例患者的感染临床症状迅速改善。17例死亡患者中，7例进行了尸检；仅4例有细菌感染迹象；1例患有结核病，1例患有巨细胞病毒感染。联合治疗耐受性良好，副作用罕见；未观察到出血并发症。未观察到两种β-内酰胺类抗生素之间可能存在拮抗作用的临床迹象。
