Jensen O M, Kamby C
Int J Cancer. 1982 May 15;29(5):507-9. doi: 10.1002/ijc.2910290504.
Animal experiments show that rats fed saccharin are more likely to develop bladder tumours if they have been exposed to saccharin in utero through their mothers' food. The risk of bladder tumours in humans following in utero exposure to saccharin has not been evaluated previously. In Denmark the use of saccharin increased sharply during the second World War as a result of scarcity of sugar, and import and export figures indicate that saccharin consumption was on average 4-5 times higher during the war-time period than in the pre-war decade. The risk of bladder tumours at ages 20-34 was 1.0 (95% confidence interval 0.7-1.6) among men born in 1941-1945 compared with men born 1931-1940. Among women the risk was 0.3 (0.1-1.0). This study provides no evidence of an increased risk of human bladder cancer during the first 30-35 years of life associated with in utero saccharine exposure.
动物实验表明，食用糖精的大鼠若在子宫内通过母体食物接触过糖精，则更有可能患上膀胱肿瘤。此前尚未评估人类在子宫内接触糖精后患膀胱肿瘤的风险。在丹麦，由于糖短缺，第二次世界大战期间糖精的使用量急剧增加，进出口数据表明，战时糖精的消费量平均比战前十年高4至5倍。与1931 - 1940年出生的男性相比，1941 - 1945年出生的男性在20 - 34岁时患膀胱肿瘤的风险为1.0（95%置信区间0.7 - 1.6）。女性的风险为0.3（0.1 - 1.0）。这项研究没有提供证据表明，在生命的最初30 - 35年里，子宫内接触糖精会增加人类患膀胱癌的风险。
